Defining the target volume for post-operative radiotherapy after D2 dissection in gastric cancer by CT-based vessel-guided delineation

Hong In Yoon, Jee Suk Chang, Joon Seok Lim, Sung Hoon Noh, Woo Jin Hyung, Ji Yeong An, Yong Chan Lee, Sun Young Rha, Kyung Hwan Kim, Woong Sub Koom

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Purpose To determine the recurrent nodal gross tumor volume (rnGTV) based on CT-guided vascular structure to refine the clinical target volume (CTV) delineation in postoperative radiotherapy for advanced gastric cancer following radical gastrectomy with D2 dissection. Materials and methods We retrospectively reviewed follow-up images from 91 patients with their first regional recurrence after D2 dissection in stage III gastric cancer with N3 disease. We defined rnGTV as recurrent nodes shown in follow-up CT images, in which one diagnostic radiologist with specialty of gastrointestinal tract investigated. We drew rnGTVs at the equivalent location based on the same vessels of reference comparing CT images to recurrence CT images. Results We propose vessel-based locations of rnGTVs on CT images with axial and coronal views. We show different patterns of regional recurrence according to the location of primary gastric cancer using CT and digitally reconstructed radiograph (DRR) images. Frequently recurred sites, overlapped by more than five rnGTVs, are depicted in a DRR image. Conclusions This study suggests vessel-based delineations of rnGTVs on CT images depending on nodal recurrence sites from follow-up images after D2 lymphadenectomy. Our results could help reduce the inter-observer variation of CTV delineation after D2 dissection in gastric cancer.

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalRadiotherapy and Oncology
Issue number1
Publication statusPublished - 2013 Jul

Bibliographical note

Funding Information:
This work was supported by the Korea Healthcare Technology R&D Project , the Ministry for Health, Welfare & Family Affairs, the Republic of Korea ( A084120 ), and research funds provided by the Seoul Metropolitan Government , Seoul Business Agency (2012).

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging


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