Dedifferentiated Schwann cells secrete progranulin that enhances the survival and axon growth of motor neurons

Sujin Hyung, Sun Kyoung Im, Bo Yoon Lee, Jihye Shin, Jong Chul Park, Cheolju Lee, Jun Kyo Francis Suh, Eun Mi Hur

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Schwann cells (SCs), the primary glia in the peripheral nervous system (PNS), display remarkable plasticity in that fully mature SCs undergo dedifferentiation and convert to repair SCs upon nerve injury. Dedifferentiated SCs provide essential support for PNS regeneration by producing signals that enhance the survival and axon regrowth of damaged neurons, but the identities of neurotrophic factors remain incompletely understood. Here we show that SCs express and secrete progranulin (PGRN), depending on the differentiation status of SCs. PGRN expression and secretion markedly increased as primary SCs underwent dedifferentiation, while PGRN secretion was prevented by administration of cAMP, which induced SC differentiation. We also found that sciatic nerve injury, a physiological trigger of SC dedifferentiation, induced PGRN expression in SCs in vivo. These results suggest that dedifferentiated SCs express and secrete PGRN that functions as a paracrine factor to support the survival and axon growth of neighboring neurons after injury.

Original languageEnglish
Pages (from-to)360-375
Number of pages16
Issue number2
Publication statusPublished - 2019 Feb

Bibliographical note

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cellular and Molecular Neuroscience


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