Abstract
Aim The potential role of soluble α-klotho in diabetic kidney disease has not yet been evaluated. The aim of this study was to evaluate the association of plasma and/or urine α-klotho with the progression of type 2 diabetic nephropathy. Methods The baseline values of plasma and urine α-klotho were measured in 147 patients with type 2 diabetes mellitus with an estimated glomerular filtration rate (eGFR) of ≥ 60 mL/min/1.73 m2. In this prospective observational study, a total of 109 type 2 diabetic patients were followed up for 34 months (8-50 months). Results Plasma α-klotho, but not urine α-klotho, was negatively correlated with the decline of eGFR (r = - 0.304, P = 0.001; r = 0.042, P = 0.068, respectively). After adjusting for several clinical parameters, baseline eGFR and urine ACR, plasma α-klotho was significantly associated with the decline of eGFR (r = - 0.219, P = 0.008). In the normoalbuminuria group (n = 63), the plasma α-klotho remained significantly associated with a decline in eGFR (r = 0.324, P = 0.004) in the final model. Conclusions It is suggested that plasma α-klotho may be an early biomarker for predicting renal impairment in type 2 diabetic patients. The disappearance of a compensatory increase of plasma α-klotho might be a predictive marker for the progression of type 2 diabetic nephropathy.
Original language | English |
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Pages (from-to) | 887-892 |
Number of pages | 6 |
Journal | Journal of Diabetes and its Complications |
Volume | 30 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2016 Jul 1 |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Inc. All rights reserved.
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology