Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia

Ok Hee Lee, Jayoung Kim, Jin Moo Kim, Hyunji Lee, Eun Hee Kim, Soo Kyung Bae, Youngsok Choi, Hyo Suk Nam, Ji Hoe Heo

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44 Citations (Scopus)


Sirtuin 6 (SIRT6) belongs to the sirtuin family of NAD+-dependent deacetylases and has been implicated in the regulation of metabolism, inflammation, and aging. Here, we found that SIRT6 was predominantly expressed in neuronal cells throughout the entire brain. Ischemia models using transient middle cerebral artery occlusion in rats and oxygen/glucose deprivation (OGD) in SH-SY5Y neuronal cells showed that ischemia reduced SIRT6 expression and induced the release of high mobility group box-1 (HMGB1) from cell nuclei. The reduced expression of SIRT6 via treatment with SIRT6 siRNA dramatically enhanced the OGD-induced release of HMGB1 in SH-SY5Y cells. Together, our data suggest that SIRT6 may serve as a potential therapeutic target for HMGB1-mediated inflammation after cerebral ischemia.

Original languageEnglish
Pages (from-to)388-394
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 2013 Aug 23

Bibliographical note

Funding Information:
We thank Ms. Hyejin Kim for technical assistance and Dr. Il Kwon for his discussion on the article. This work was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( 2010-0004950 ), by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs , ( A085136 ), and by a faculty research grant of Yonsei University College of Medicine (Nos. 8-2010-0022 and 8-2011-0014 ).

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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