Decreased caudal anterior cingulate gyrus volume and positive symptoms in schizophrenia

Jung Seok Choi, Do Hyung Kang, Jae Jin Kim, Tae Hyun Ha, Kyu Sik Roh, Tak Youn, Jun Soo Kwon

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


The anterior cingulate gyrus is a heterogeneous region that has specialized subdivisions with respect to its cytoarchitecture, function and connectivity. The aim of this study was to examine the morphological changes of the caudal subdivision of the anterior cingulate gyrus in the context of the cortico-striatal-thalamo-cortical circuitry of schizophrenia and their relationship to clinical symptoms. Accordingly, we measured the volumes of the caudal and rostral anterior cingulate gyrus, the orbitofrontal cortex, the caudate and the thalamus by magnetic resonance imaging in age- and sex-matched groups, which consisted of 22 patients with schizophrenia and 22 normal volunteers. The clinical symptoms of schizophrenia patients were obtained using the Positive and Negative Syndrome Scale. Volumetric reduction of the right caudal anterior cingulate gyrus was observed in patients with schizophrenia as compared with the normal controls. Furthermore, a smaller volume of the caudal anterior cingulate gyrus was significantly correlated with more severe positive symptoms of schizophrenia. Thus, these findings suggest that a volumetric abnormality of the caudal anterior cingulate gyrus in schizophrenia may be related to positive symptoms and possibly involved in the pathophysiology of schizophrenia.

Original languageEnglish
Pages (from-to)239-247
Number of pages9
JournalPsychiatry Research - Neuroimaging
Issue number3
Publication statusPublished - 2005 Aug 30

Bibliographical note

Funding Information:
This research was supported by a grant (M103KV010007 04K2201 00710) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of Republic of Korea.

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


Dive into the research topics of 'Decreased caudal anterior cingulate gyrus volume and positive symptoms in schizophrenia'. Together they form a unique fingerprint.

Cite this