Decellularized tissue matrix for stem cell and tissue engineering

Jung Seung Lee, Yi Sun Choi, Seung Woo Cho

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)


Decellularization is a technique to remove cellular components from native tissues, which could reduce immune reactions to the scaffolds. Decellularized matrices are valuable for tissue engineering, as they preserve tissue-specific structural, mechanical, and biochemical microenvironments, while promoting cellular engraftment and functions in the matrix. So far, various tissues have been decellularized by combinations of mechanical, chemical, and enzymatic processes and utilized in preparing bioscaffolds to provide tissue-specific environments for various cell types, including primary cells, progenitor cells, and stem cells. In addition, decellularized matrices could be manipulated into several formats according to the final application, such as tissue-engineering scaffolds, artificial organs, cell culture matrices, and transplantation carriers. In this chapter, we describe various types of decellularized tissue matrices and their extensive use in regenerative medicine, including reconstruction of artificial organs and regeneration of damaged tissues.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages20
Publication statusPublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2018.

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


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