Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines

Chung Kyu Ryu; Hye Young Kang; Yu Jin Yi; Chong Ock Lee

doi:10.1007/BF02976464

Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines

Chung Kyu Ryu, Hye Young Kang, Yu Jin Yi, Chong Ock Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl)amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.

Original language	English
Pages (from-to)	42-45
Number of pages	4
Journal	Archives of pharmacal research
Volume	23
Issue number	1
DOIs	https://doi.org/10.1007/BF02976464
Publication status	Published - 2000 Feb

Bibliographical note

Funding Information:
The authors wish to acknowledge the financial support of the MOST through National R&D Program (97-N6-01-01-A-18 ) for Women's Universities. We thank Dr. Chang Yong Hong (Biotech Research Institute, LG Research Park, Taejon 305-380, Korea) for the testing of CDKs inhibitory activities.

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/BF02976464

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title = "Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines",

abstract = "6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl)amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.",

author = "Ryu, {Chung Kyu} and Kang, {Hye Young} and Yi, {Yu Jin} and Lee, {Chong Ock}",

note = "Funding Information: The authors wish to acknowledge the financial support of the MOST through National R&D Program (97-N6-01-01-A-18 ) for Women's Universities. We thank Dr. Chang Yong Hong (Biotech Research Institute, LG Research Park, Taejon 305-380, Korea) for the testing of CDKs inhibitory activities.",

year = "2000",

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doi = "10.1007/BF02976464",

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AU - Ryu, Chung Kyu

AU - Kang, Hye Young

AU - Yi, Yu Jin

AU - Lee, Chong Ock

N1 - Funding Information: The authors wish to acknowledge the financial support of the MOST through National R&D Program (97-N6-01-01-A-18 ) for Women's Universities. We thank Dr. Chang Yong Hong (Biotech Research Institute, LG Research Park, Taejon 305-380, Korea) for the testing of CDKs inhibitory activities.

PY - 2000/2

Y1 - 2000/2

N2 - 6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl)amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.

AB - 6-Arylamino-7-halo-5,8-quinolinediones (4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl)amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.

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Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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