Cytokine profile of peripheral blood in type 2 diabetes mellitus patients with diabetic retinopathy

Jong Han Lee, Woonhyung Lee, Hun Kwon Oh, Jeong Ho Kim, Woong Kwon Oh, Hwan Kim Kyung, Jong Baeck Lim

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52 Citations (Scopus)


To evaluate the usefulness of cytokine levels of peripheral blood in diabetic retinopathy (DR), demographic and biochemical parameters including low-density lipoprotein (LDL) diameter as well as cytokine profiles were analyzed in 74 patients with type 2 diabetes mellitus (DM), with DR (n = 46) or without DR (n = 28). DM duration was longer in the patients with DR than without (p <0.001). Serum glucose (p = 0.005) and total cholesterol (p = 0.029) levels were higher in DM patients with DR than DM patients without DR. Plasma LDL diameter, interleukin-6 (IL-6), and interleukin-8 (IL-8) showed significant differences among the different degrees of DR severity in analysis of variance (ANOVA) with no definite trend. The risk of DR in DM patients was decreased by an increase of interleukin-10 (IL-10) level [odds ratio (OR) = 0.152; confidence interval (CI): 0.028-0.817]. Plasma LDL diameter was smaller and IL-6 and tumor necrosis factor-alpha (TNF-α) levels were higher in DM patients with proliferative diabetic retinopathy (PDR) compared to those with non-proliferative diabetic retinopathy (NPDR) (p <0.05). We found that higher IL-10 levels were related to lower risk of DR in DM patients. Levels of IL-6 and TNF-α as well as LDL diameter may be helpful in the prediction of PDR in DM patients with DR.

Original languageEnglish
Pages (from-to)361-367
Number of pages7
JournalAnnals of Clinical and Laboratory Science
Issue number4
Publication statusPublished - 2008 Sept

All Science Journal Classification (ASJC) codes

  • General Medicine


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