Cyclooxygenase-2 expression in proliferative Ki-67-positive breast cancers is associated with poor outcomes

Byeong Woo Park, Seho Park, Hyung Seok Park, Ja Seung Koo, Woo Ick Yang, Jun Sang Lee, Hyewon Hwang, Seung Il Kim, Kyong Sik Lee

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26 Citations (Scopus)


In order to investigate the implications of cyclooxygenase-2 (COX-2) expression in combination with Ki-67 on breast cancer outcomes, the COX-2 and Ki-67 expression levels and other clinicopathologic parameters were investigated in 861 breast cancers. Clini-copathological parameters and survival were investigated in association with the expression levels of both COX-2 and Ki-67 using univariate and multivariate analyses. COX-2 expression was positive in 493 (57.3%) of invasive tumors. COX-2 was associated with favorable markers, but was not related to survival outcome by itself. However, COX-2 in proliferative tumors [COX-2(+)/Ki-67(+)] were significantly associated with unfavorable factors and the worst survival, but COX-2 in non-proliferative tumors [COX-2(+)/Ki-67(-)] showed significantly favorable parameters and better outcomes. COX-2(-)/Ki-67(any) showed intermediate prognosis. The statistical significance was maintained in stage-matched and multivariate analyses. The results of present study suggest that COX-2 expression is a common event in breast cancers and may play in a different ways by the proliferation status of the tumor cells. Further studies should be carried out to verify the role of COX-2 by proliferative conditions of breast tumor cells.

Original languageEnglish
Pages (from-to)741-751
Number of pages11
JournalBreast Cancer Research and Treatment
Issue number2
Publication statusPublished - 2012 Jun

Bibliographical note

Funding Information:
Acknowledgments A major part of this study was presented at the 34th Annual San Antonio Breast Cancer Symposium, Poster session, December 6-10, 2011, in San Antonio, TX, USA. This work was supported by the Brain Korea 21 Project for Medical Science, Yonsei University, and in part by a grant-in-aid from Sanofi-Aventis Pharmaceutical Co. and Dong-A Pharmaceutical Co.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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