Curved biodegradable microneedles for vascular drug delivery

Chang Kuk Choi; Jin Bum Kim; Eui Hwa Jang; Young Nam Youn; Won Hyoung Ryu

doi:10.1002/smll.201200441

Curved biodegradable microneedles for vascular drug delivery

Chang Kuk Choi, Jin Bum Kim, Eui Hwa Jang, Young Nam Youn, Won Hyoung Ryu

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied.

Original language	English
Pages (from-to)	2483-2488
Number of pages	6
Journal	Small
Volume	8
Issue number	16
DOIs	https://doi.org/10.1002/smll.201200441
Publication status	Published - 2012 Aug 20

All Science Journal Classification (ASJC) codes

Biotechnology
Biomaterials
Chemistry(all)
Materials Science(all)

Access to Document

10.1002/smll.201200441

Cite this

@article{5bba800f80c34af79e181d3d765050de,

title = "Curved biodegradable microneedles for vascular drug delivery",

abstract = "Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied.",

author = "Choi, {Chang Kuk} and Kim, {Jin Bum} and Jang, {Eui Hwa} and Youn, {Young Nam} and Ryu, {Won Hyoung}",

year = "2012",

month = aug,

day = "20",

doi = "10.1002/smll.201200441",

language = "English",

volume = "8",

pages = "2483--2488",

journal = "Small",

issn = "1613-6810",

publisher = "Wiley-VCH Verlag",

number = "16",

}

TY - JOUR

T1 - Curved biodegradable microneedles for vascular drug delivery

AU - Choi, Chang Kuk

AU - Kim, Jin Bum

AU - Jang, Eui Hwa

AU - Youn, Young Nam

AU - Ryu, Won Hyoung

PY - 2012/8/20

Y1 - 2012/8/20

N2 - Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied.

AB - Curved biodegradable microneedles for application to the outer surface of blood vessels are produced to enhance drug delivery to vascular tissues suffering from hyperplasia or atherosclerosis. Spatially discrete thermal drawing and post-annealing processes are employed to fabricate microneedles on a curved surface. Insertion of microneedles into arteries in vivo and ex vivo is demonstrated, and their mechanical properties and drug-delivery function are studied.

UR - http://www.scopus.com/inward/record.url?scp=84864694818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864694818&partnerID=8YFLogxK

U2 - 10.1002/smll.201200441

DO - 10.1002/smll.201200441

M3 - Article

C2 - 22628194

AN - SCOPUS:84864694818

SN - 1613-6810

VL - 8

SP - 2483

EP - 2488

JO - Small

JF - Small

IS - 16

ER -

Curved biodegradable microneedles for vascular drug delivery

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this