Cumulative effects of prenatal substance exposure and early adversity on foster children's HPA-axis reactivity during a psychosocial stressor

Philip A. Fisher; Hyoun K. Kim; Jacqueline Bruce; Katherine C. Pears

doi:10.1177/0165025411406863

Cumulative effects of prenatal substance exposure and early adversity on foster children's HPA-axis reactivity during a psychosocial stressor

Philip A. Fisher, Hyoun K. Kim, Jacqueline Bruce, Katherine C. Pears

Department of Child and family Studies

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Dysregulated hypothalamic-pituitary-adrenocortical (HPA) axis stress response has been reported among individuals with prenatal substance exposure and those with early adversity exposure. However, few researchers have examined the combined effects of these risk factors. Patterns of HPA reactivity among maltreated foster children with and without prenatal substance exposure (N = 53; ages 9-12 years) were examined using the Trier Social Stress Test for Children. Area under the curve with respect to increase (AUC_I) analyses revealed that prenatal substance exposure or physical abuse significantly increased the likelihood of a negative AUC_I (i.e., little or no HPA reactivity). Among children with prenatal substance exposure and physical abuse, 85% exhibited a negative AUC_I. The results underscore the importance of addressing this combined risk.

Original language	English
Pages (from-to)	29-35
Number of pages	7
Journal	International Journal of Behavioral Development
Volume	36
Issue number	1
DOIs	https://doi.org/10.1177/0165025411406863
Publication status	Published - 2012 Jan

Bibliographical note

Funding Information:
Support for this project was provided by the following grants: MH059780 and MH078105, NIMH, U.S. PHS; HD045894, NICHD, U.S. PHS; and DA021424 and DA023920, NIDA, U.S. PHS. Astley S. J. Clarren S. K . ( 2001 ).

All Science Journal Classification (ASJC) codes

Social Psychology
Education
Developmental and Educational Psychology
Social Sciences (miscellaneous)
Developmental Neuroscience
Life-span and Life-course Studies

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abstract = "Dysregulated hypothalamic-pituitary-adrenocortical (HPA) axis stress response has been reported among individuals with prenatal substance exposure and those with early adversity exposure. However, few researchers have examined the combined effects of these risk factors. Patterns of HPA reactivity among maltreated foster children with and without prenatal substance exposure (N = 53; ages 9-12 years) were examined using the Trier Social Stress Test for Children. Area under the curve with respect to increase (AUCI) analyses revealed that prenatal substance exposure or physical abuse significantly increased the likelihood of a negative AUCI (i.e., little or no HPA reactivity). Among children with prenatal substance exposure and physical abuse, 85% exhibited a negative AUCI. The results underscore the importance of addressing this combined risk.",

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Cumulative effects of prenatal substance exposure and early adversity on foster children's HPA-axis reactivity during a psychosocial stressor

Abstract

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