Cryoablation of Hepatocellular Carcinoma with High-Risk for Percutaneous Ablation: Safety and Efficacy

Gyoung Min Kim, Jong Yun Won, Man Deuk Kim, Sung Il Park, Do Yun Lee, Wonseon Shin, Minwoo Shin, Kwang Hyub Han, Do Young Kim, Seung Up Kim

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Purpose: The aim of this study was to evaluate the safety and effectiveness of cryoablation in the treatment of subcapsular hepatocellular carcinoma (HCC) adjacent to various organs. Materials and Methods: Twenty-eight patients with subcapsular HCC were treated with cryoablation in our institution. The degree of peri-procedural pain was measured using the visual analog scale (VAS). Technical success, local tumor progression, and overall disease progression rates were calculated. Procedure-related complications were identified by reviewing electronic medical records. Biochemical data, including serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin levels before and after the procedure were collected. Results: Subcapsular HCC tumors were located near the gallbladder, colon, stomach, kidney, diaphragm, or abdominal wall. The technical success rate of cryoablation was 96.4 % (27/28). Local recurrence- and progression-free survival rates were 96 and 84 % at 6 months, and 82 and 43 % at 1 year, respectively. All patients survived during the follow-up period. The VAS pain score ranged from 0 to 3 (mean, 1.57). A major complication occurred in one patient (3.6 %) and minor complications occurred at a rate of 17.9 %. Transient elevations of serum AST, ALT, and bilirubin levels were observed. Conclusion: Cryoablation is a safe and an effective procedure for the treatment of subcapsular HCC adjacent to various major organs.

Original languageEnglish
Pages (from-to)1447-1454
Number of pages8
JournalCardiovascular and interventional radiology
Issue number10
Publication statusPublished - 2016 Oct 1

Bibliographical note

Publisher Copyright:
© 2016, Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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