Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression

Se Heon Kim, Nam Hoon Cho, Kyubo Kim, Jin Seok Lee, Bon Seok Koo, Jeong Hong Kim, Jung Hyun Chang, Eun Chang Choi

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)


Background and Objectives: In oral tongue cancer, the degree of tumor invasion has a significant effect on the prognosis. We hypothesized that the destruction of extracelluar matrix and neovascularization are related to tumor infiltration mechanism. By studying the tissues of early stage oral tongue cancer patients, we are intending to clarify the invasion-related factors. Materials and Methods: To demonstrate the invasion process in early T-stage oral tongue cancer, the expressions of extracellular matrix destruction-related molecules (MMP-2, MMP-9) and neovascularization-related molecule (VEGF) were observed by immunohistochemical study. Also, staining of CD31 was done for quantification of neovascularization. We analyzed relationship between expression of each substances and tumor invasion depth, tumor free survival rates, and cervical lymph node metastasis rate. Results: The expression rates of MMP-2, MMP-9, VEGF in 38 early oral cancer patients were 52.6%, 78.9%, and 52.6%, respectively. Significant correlation was found between the VEGF expression and microvessel density showed by CD31 immunohistochemical staining (P < 0.001). VEGF expressions were significantly related with tumor invasion depth (P = 0.002). The tumor-free survival rate of those patients with VEGF-positive tumors was significantly poorer than in those with VEGF-negative tumors (P = 0.019). Conclusions: These results indicate that VEGF is a useful marker for predicting the tumor invasion in patients with early tongue cancer.

Original languageEnglish
Pages (from-to)330-337
Number of pages8
JournalJournal of Histotechnology
Issue number4
Publication statusPublished - 2006 Mar 15

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Histology
  • Medical Laboratory Technology


Dive into the research topics of 'Correlations of oral tongue cancer invasion with matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) expression'. Together they form a unique fingerprint.

Cite this