Correlation between midthigh low-density muscle and insulin resistance in obese nondiabetic patients in Korea

Dolmi Kim, Suyoun Nam, Chulwoo Ahn, Kyungwook Kim, Soojee Yoon, Junuh Kim, Bongsoo Cha, Sungkil Lim, Kyungrae Kim, Hyunchul Lee, Kapbum Huh

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


OBJECTIVE - We investigated the link between lipid-rich skeletal muscle, namely low-density muscle, and insulin resistance in Korea. RESEARCH DESIGN AND METHODS - Abdominal adipose tissue areas and midthigh skeletal muscle areas of 75 obese nondiabetic subjects (23 men, 52 women; mean age ± SD, 41.9 ± 14.1 years) were measured by computed tomography (CT). The midthigh skeletal muscle areas were subdivided into low-density muscle (0 to +30 Hounsfield units) and normal-density muscle (+31 to +100 Hounsfield units). The homeostasis model assessment (HOMA) score was calculated to assess whole-body insulin sensitivity. RESULTS - The abdominal visceral fat area and the midthigh low-density muscle area were found to be well correlated with the HOMA score (r = 0.471, P < 0.01 and r = 0.513, P < 0.01, respectively). The correlation between low-density muscle area and insulin resistance persisted after adjusting for BMI or total body fat mass (r = 0.451, P < 0.01 and r = 0.522, P < 0.01, respectively) and even after adjusting for abdominal visceral fat area (r = 0.399, P < 0.01). CONCLUSIONS - The midthigh low-density muscle area seems to be a reliable determinant of insulin resistance in Korean obese nondiabetic patients.

Original languageEnglish
Pages (from-to)1825-1830
Number of pages6
JournalDiabetes Care
Issue number6
Publication statusPublished - 2003 Jun 1

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing


Dive into the research topics of 'Correlation between midthigh low-density muscle and insulin resistance in obese nondiabetic patients in Korea'. Together they form a unique fingerprint.

Cite this