This study aimed to fabricate core/sheath-structured composite nanofibers containing cinnamon oil by emulsion electrospinning and to investigate their acaricidal effect on house dust mites as well as their antibacterial and antifungal properties in relation to cinnamon oil concentration in the nanofibers. An oil-in-water emulsion, which comprised cinnamon oil and poly(vinyl alcohol) solution as oil and water phases, respectively, was used to prepare core/sheath-structured nanofibers. The morphology and the inner structure of the electrospun nanofibers were observed by scanning electron microscopy and confocal laser scanning microscopy. Core/sheath-structured nanofibers containing cinnamon oil were successfully prepared by emulsion electrospinning. The composite nanofibers prepared from an emulsion containing 20 wt% of cinnamon oil exhibited a strong acaricidal effect against house dust mites (Dermatophagoides farinae). The composite nanofibers fabricated from an emulsion containing 4.29 wt% of cinnamon oil showed excellent antimicrobial effects against Staphylococcus aureus and a series of fungi that can trigger respiratory-and skin-related diseases. The release profile of cinnamon oil from the core/sheath-structured nanofibers showed a continuous release of functional ingredients over 28 days. Our findings demonstrate that the use of such fibrous structures could be a promising approach for delivering naturally derived bioactive agents in a controlled way.
|Publication status||Published - 2020 Jan 1|
Bibliographical noteFunding Information:
Funding: This research was funded by JSPS KAKENHI: 18H05158, 19H02696, 19K15629, 19K22179, 19K21963; JST CREST: JPMJCR19l2; ERCA Japan: 5RF-1802.
This research was funded by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, project NRF-2016R1D1A1B03930882; and the Brain Korea 21 Plus Project of Dept. of Clothing and Textiles, Yonsei University in 2019.
Acknowledgments: The authors would appreciate Tatsuo Kojima and Shuichi Hiraoka for their helpful access on mass measurements. This research was supported by financial supports (JSPS Research Fellow, Yazaki Memorial Foundation for Science and Technology, Asahi Glass Foundation, The Amada Foundation, Izumi Science and Technology Foundation, Yashima Environment Technology Foundation, and Iketani Science and Technology Foundation).
© 2020 by the authors.
All Science Journal Classification (ASJC) codes
- Polymers and Plastics