Controlled release of donepezil intercalated in smectite clays

Jin Kuen Park, Young Bin Choy, Jae Min Oh, Ju Young Kim, Seong Ju Hwang, Jin Ho Choy

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210 Citations (Scopus)


The inorganic-organic hybrid for a drug delivery system was successfully realized by intercalating donepezil molecules into smectite clays (laponite XLG, saponite, and montmorillonite). According to the powder XRD patterns, TG profiles, and FT-IR spectra, itwas confirmed that donepezil moleculeswerewell stabilized in the interlayer space of clay via mono or double layer stacking. The adsorption amount and molecular structure of donepezil appeared to depend on the cation exchange capacity of the clay, which in turn, tailored the drug release patterns. Especially in the presence of a bulky cationic polymer (Eudragit® E-100) in the releasemedia, the release ratewas found to be improved due to its effective replacement with intercalated donepezil molecules. Therefore, to formulate a complete drug delivery system, the hybrids were coated with Eudragit® E-100 using a spray dryer, which also showed great enhancement in the release rate during a short period of time (180 min).

Original languageEnglish
Pages (from-to)198-204
Number of pages7
JournalInternational Journal of Pharmaceutics
Issue number1-2
Publication statusPublished - 2008 Jul 9

Bibliographical note

Funding Information:
This work was financially supported by the SRC/ERC program of MOST/KOSEF through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (grant: R11-2005-008-00000-0) and also partly supported by the Ministry of Commerce, Industry and Energy (MOCIE) through the project of NGNT (No. 10024135-2005-11) and “Seoul Research and Business Development Program (10816)”.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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