Controlled delivery of a hydrophilic drug from a biodegradable microsphere system by supercritical anti-solvent precipitation technique

S. Lee; M. S. Kim; J. S. Kim; H. J. Park; J. S. Woo; B. C. Lee; Sung Joo Hwang

doi:10.1080/09687860600945552

Controlled delivery of a hydrophilic drug from a biodegradable microsphere system by supercritical anti-solvent precipitation technique

S. Lee, M. S. Kim, J. S. Kim, H. J. Park, J. S. Woo, B. C. Lee, Sung Joo Hwang

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The purpose of this study was to prepare microspheres loaded with hydrophilic drug, bupivacaine HCl using poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(L-lactic acid) (PLLA). Microspheres were prepared with varying the PLGA/PLLA ratio with two different levels of bupivacaine HCl (5 and 10%) using a supercritical anti-solvent (SAS) technique. Microspheres ranging from 4-10 μm in geometric mean diameter could be prepared, with high loading efficiency. Powder X-ray diffraction (PXRD) revealed that bupivacaine HCl retained its crystalline state within the polymer and was present as a dispersion within the polymer phase after SAS processing. The release of bupivacaine HCl from biodegradable polymer microspheres was rapid up to 4h, thereafter bupivacaine HCl was continuously and slowly released for at least 7 days according to the PLGA/PLLA ratio and the molecular weight of PLLA.

Original language	English
Pages (from-to)	741-749
Number of pages	9
Journal	Journal of Microencapsulation
Volume	23
Issue number	7
DOIs	https://doi.org/10.1080/09687860600945552
Publication status	Published - 2006 Nov

Bibliographical note

Funding Information:
This work was supported in part by the National Research Laboratory program (M1-0302-00-0016) in the series of MOST-NRDP in the Ministry of Science and Technology, Korea.

All Science Journal Classification (ASJC) codes

Bioengineering
Pharmaceutical Science
Physical and Theoretical Chemistry
Organic Chemistry
Colloid and Surface Chemistry

Access to Document

10.1080/09687860600945552

Cite this

@article{789691bf1a074e7790f42374cfeb7b9d,

title = "Controlled delivery of a hydrophilic drug from a biodegradable microsphere system by supercritical anti-solvent precipitation technique",

abstract = "The purpose of this study was to prepare microspheres loaded with hydrophilic drug, bupivacaine HCl using poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(L-lactic acid) (PLLA). Microspheres were prepared with varying the PLGA/PLLA ratio with two different levels of bupivacaine HCl (5 and 10%) using a supercritical anti-solvent (SAS) technique. Microspheres ranging from 4-10 μm in geometric mean diameter could be prepared, with high loading efficiency. Powder X-ray diffraction (PXRD) revealed that bupivacaine HCl retained its crystalline state within the polymer and was present as a dispersion within the polymer phase after SAS processing. The release of bupivacaine HCl from biodegradable polymer microspheres was rapid up to 4h, thereafter bupivacaine HCl was continuously and slowly released for at least 7 days according to the PLGA/PLLA ratio and the molecular weight of PLLA.",

author = "S. Lee and Kim, {M. S.} and Kim, {J. S.} and Park, {H. J.} and Woo, {J. S.} and Lee, {B. C.} and Hwang, {Sung Joo}",

note = "Funding Information: This work was supported in part by the National Research Laboratory program (M1-0302-00-0016) in the series of MOST-NRDP in the Ministry of Science and Technology, Korea.",

year = "2006",

month = nov,

doi = "10.1080/09687860600945552",

language = "English",

volume = "23",

pages = "741--749",

journal = "Journal of Microencapsulation",

issn = "0265-2048",

publisher = "Informa Healthcare",

number = "7",

}

TY - JOUR

T1 - Controlled delivery of a hydrophilic drug from a biodegradable microsphere system by supercritical anti-solvent precipitation technique

AU - Lee, S.

AU - Kim, M. S.

AU - Kim, J. S.

AU - Park, H. J.

AU - Woo, J. S.

AU - Lee, B. C.

AU - Hwang, Sung Joo

N1 - Funding Information: This work was supported in part by the National Research Laboratory program (M1-0302-00-0016) in the series of MOST-NRDP in the Ministry of Science and Technology, Korea.

PY - 2006/11

Y1 - 2006/11

N2 - The purpose of this study was to prepare microspheres loaded with hydrophilic drug, bupivacaine HCl using poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(L-lactic acid) (PLLA). Microspheres were prepared with varying the PLGA/PLLA ratio with two different levels of bupivacaine HCl (5 and 10%) using a supercritical anti-solvent (SAS) technique. Microspheres ranging from 4-10 μm in geometric mean diameter could be prepared, with high loading efficiency. Powder X-ray diffraction (PXRD) revealed that bupivacaine HCl retained its crystalline state within the polymer and was present as a dispersion within the polymer phase after SAS processing. The release of bupivacaine HCl from biodegradable polymer microspheres was rapid up to 4h, thereafter bupivacaine HCl was continuously and slowly released for at least 7 days according to the PLGA/PLLA ratio and the molecular weight of PLLA.

AB - The purpose of this study was to prepare microspheres loaded with hydrophilic drug, bupivacaine HCl using poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(L-lactic acid) (PLLA). Microspheres were prepared with varying the PLGA/PLLA ratio with two different levels of bupivacaine HCl (5 and 10%) using a supercritical anti-solvent (SAS) technique. Microspheres ranging from 4-10 μm in geometric mean diameter could be prepared, with high loading efficiency. Powder X-ray diffraction (PXRD) revealed that bupivacaine HCl retained its crystalline state within the polymer and was present as a dispersion within the polymer phase after SAS processing. The release of bupivacaine HCl from biodegradable polymer microspheres was rapid up to 4h, thereafter bupivacaine HCl was continuously and slowly released for at least 7 days according to the PLGA/PLLA ratio and the molecular weight of PLLA.

UR - http://www.scopus.com/inward/record.url?scp=33751365981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751365981&partnerID=8YFLogxK

U2 - 10.1080/09687860600945552

DO - 10.1080/09687860600945552

M3 - Article

C2 - 17123918

AN - SCOPUS:33751365981

SN - 0265-2048

VL - 23

SP - 741

EP - 749

JO - Journal of Microencapsulation

JF - Journal of Microencapsulation

IS - 7

ER -

Controlled delivery of a hydrophilic drug from a biodegradable microsphere system by supercritical anti-solvent precipitation technique

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this