Continuous-Flow Kinetic Resolution of (±)- cis -1-Amino-2-indanol by Lipase-Catalyzed N-Acetylation

Yoon Jung Kim; Yong Sung Choi; Sai Yang; Woo Ram Yang; Jin Hyun Jeong

doi:10.1055/s-0034-1380427

Continuous-Flow Kinetic Resolution of (±)- cis -1-Amino-2-indanol by Lipase-Catalyzed N-Acetylation

Yoon Jung Kim, Yong Sung Choi, Sai Yang, Woo Ram Yang, Jin Hyun Jeong

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Selective N-acetylation of (1S,2R)-1-amino-2-indanol by immobilized lipase B from Candida antarctica showed high enantiomeric excess when ethyl acetate was used as the acyl donor in a THF solution. Combining this process with continuous-flow system, we could obtain enantiomerically pure N-acetyl-aminoindanol at a flow rate of 0.1 mL/min (residence time of 64 min). It has been demonstrated to be more efficient compared to the flask mode.

Original language	English
Article number	st-2015-u0295-l
Pages (from-to)	1981-1984
Number of pages	4
Journal	Synlett
Volume	26
Issue number	14
DOIs	https://doi.org/10.1055/s-0034-1380427
Publication status	Published - 2015 Sept 1

Bibliographical note

Publisher Copyright:
© Georg Thieme Verlag Stuttgart New York Synlett 2015.

All Science Journal Classification (ASJC) codes

Organic Chemistry

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abstract = "Selective N-acetylation of (1S,2R)-1-amino-2-indanol by immobilized lipase B from Candida antarctica showed high enantiomeric excess when ethyl acetate was used as the acyl donor in a THF solution. Combining this process with continuous-flow system, we could obtain enantiomerically pure N-acetyl-aminoindanol at a flow rate of 0.1 mL/min (residence time of 64 min). It has been demonstrated to be more efficient compared to the flask mode.",

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AU - Choi, Yong Sung

AU - Yang, Sai

AU - Yang, Woo Ram

AU - Jeong, Jin Hyun

PY - 2015/9/1

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N2 - Selective N-acetylation of (1S,2R)-1-amino-2-indanol by immobilized lipase B from Candida antarctica showed high enantiomeric excess when ethyl acetate was used as the acyl donor in a THF solution. Combining this process with continuous-flow system, we could obtain enantiomerically pure N-acetyl-aminoindanol at a flow rate of 0.1 mL/min (residence time of 64 min). It has been demonstrated to be more efficient compared to the flask mode.

AB - Selective N-acetylation of (1S,2R)-1-amino-2-indanol by immobilized lipase B from Candida antarctica showed high enantiomeric excess when ethyl acetate was used as the acyl donor in a THF solution. Combining this process with continuous-flow system, we could obtain enantiomerically pure N-acetyl-aminoindanol at a flow rate of 0.1 mL/min (residence time of 64 min). It has been demonstrated to be more efficient compared to the flask mode.

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Continuous-Flow Kinetic Resolution of (±)- cis -1-Amino-2-indanol by Lipase-Catalyzed N-Acetylation

Abstract

Bibliographical note

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