Continuous-Flow Kinetic Resolution of (±)- cis -1-Amino-2-indanol by Lipase-Catalyzed N-Acetylation

Yoon Jung Kim, Yong Sung Choi, Sai Yang, Woo Ram Yang, Jin Hyun Jeong

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Selective N-acetylation of (1S,2R)-1-amino-2-indanol by immobilized lipase B from Candida antarctica showed high enantiomeric excess when ethyl acetate was used as the acyl donor in a THF solution. Combining this process with continuous-flow system, we could obtain enantiomerically pure N-acetyl-aminoindanol at a flow rate of 0.1 mL/min (residence time of 64 min). It has been demonstrated to be more efficient compared to the flask mode.

Original languageEnglish
Article numberst-2015-u0295-l
Pages (from-to)1981-1984
Number of pages4
Issue number14
Publication statusPublished - 2015 Sept 1

Bibliographical note

Publisher Copyright:
© Georg Thieme Verlag Stuttgart New York Synlett 2015.

All Science Journal Classification (ASJC) codes

  • Organic Chemistry


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