Constrained optimal control applied to vaccination for influenza

Jungeun Kim, Hee Dae Kwon, Jeehyun Lee

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The efficient time schedule and prioritization of vaccine supplies are important in mitigating impact of an influenza pandemic. In practice, there are restrictions associated with limited vaccination coverage and the maximum daily vaccine administration. We extend previous work on optimal control for influenza to reflect these realistic restrictions using mixed constraints on state and control variables. An optimal control problem is formulated with the aim of minimizing the number of infected individuals while considering intervention costs. Time-dependent vaccination is computed and analysed using a model incorporating heterogeneity in population structure under different settings of transmissibility levels, vaccine coverages, and time delays.

Original languageEnglish
Pages (from-to)2313-2329
Number of pages17
JournalComputers and Mathematics with Applications
Issue number11
Publication statusPublished - 2016 Jun 1

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd.

All Science Journal Classification (ASJC) codes

  • Modelling and Simulation
  • Computational Theory and Mathematics
  • Computational Mathematics


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