@inproceedings{2da17fa6bbf24c2c99bf525ca343f557,
title = "Confocal fluorescence detection for 3D cultured mammalian cells in a microfluidic cell culture system",
abstract = "We have investigated a confocal fluorescence detection system for 3D cultured mammalian cells in a microfluidic cell culture analog system. For direct measurement of metabolic changes in the microfluidic cell culture systems using 3D cell cultures, we constructed a compact and portable confocal fluorescence detection system based on discrete optical components. The confocal detection system was designed to provide a depth scan in situ without lateral imaging for fast scanning and acquisition of average fluorescence variation associated with a large number of cells in 3D cultures of microfluidic devices. The results were consistent with the data obtained by a standard confocal microscope and suggest the potential for monitoring cell dynamics in 3D cell-based assays.",
author = "Choi, {Jong Ryul} and Sung, {Jong Hwan} and Shuler, {Michael L.} and Donghyun Kim",
year = "2010",
doi = "10.1117/12.841729",
language = "English",
isbn = "9780819479648",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII",
note = "Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII ; Conference date: 23-01-2010 Through 25-01-2010",
}