@article{8dadd6b54c474667a405eef3ce66590f,
title = "Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction",
abstract = "Purpose: The present study aimed to investigate the impact of high-sensitivity C-reactive protein (hs-CRP) and renal dysfunction on clinical outcomes in acute myocardial infarction (AMI) patients. Materials and Methods: The study involved a retrospective cohort of 8332 patients admitted with AMI. The participants were divided into 4 groups according to the levels of estimated glomerular filtration rate (eGFR) and hs-CRP: group I, no renal dysfunction (eGFR ≥60 mL·min-1·1.73 m-2) with low hs-CRP (≤2.0 mg/dL); group II, no renal dysfunction with high hs-CRP; group III, renal dysfunction with low hs-CRP; and group IV, renal dysfunction with high hs-CRP. We compared major adverse cardiac events (MACE) over a 1-year follow-up period. Results: The 4 groups demonstrated a graded association with increased MACE rates (group I, 8.8%; group II, 13.8%; group III, 18.6%; group IV, 30.1%; p<0.001). In a Cox proportional hazards model, mortality at 12 months increased in groups II, III, and IV compared with group I [hazard ratio (HR) 2.038, 95% confidence interval (CI) 1.450-2.863, p<0.001; HR 3.003, 95% CI 2.269-3.974, p<0.001; HR 5.087, 95% CI 3.755-6.891, p<0.001]. Conclusion: High hs-CRP, especially in association with renal dysfunction, is related to the occurrence of composite MACE, and indicates poor prognosis in AMI patients.",
author = "Kang, {Yong Un} and Kim, {Min Jee} and Choi, {Joon Seok} and Kim, {Chang Seong} and Bae, {Eun Hui} and Ma, {Seong Kwon} and Ahn, {Young Keun} and Jeong, {Myung Ho} and Kim, {Young Jo} and Cho, {Myeong Chan} and Kim, {Chong Jin} and Kim, {Soo Wan} and Jeong, {Myung Ho} and Ahn, {Young Keun} and Chae, {Sung Chull} and Kim, {Jong Hyun} and Hur, {Seung Ho} and Kim, {Young Jo} and Seong, {In Whan} and Choi, {Dong Hoon} and Chae, {Jei Keon} and Hong, {Taek Jong} and Rhew, {Jae Young} and Kim, {Doo Il} and Chae, {In Ho} and Yoon, {Jung Han} and Koo, {Bon Kwon} and Kim, {Byung Ok} and Lee, {Myoung Yong} and Kim, {Kee Sik} and Hwang, {Jin Yong} and Oh, {Seok Kyu} and Lee, {Nae Hee} and Jeong, {Kyoung Tae} and Tahk, {Seung Jea} and Bae, {Jang Ho} and Rha, {Seung Woon} and Park, {Keum Soo} and Han, {Kyoo Rok} and Ahn, {Tae Hoon} and Kim, {Moo Hyun} and Seung, {Ki Bae} and Chung, {Wook Sung} and Yang, {Ju Young} and Rhim, {Chong Yun} and Gwon, {Hyeon Cheol} and Park, {Seong Wook} and Koh, {Young Youp} and Joo, {Seung Jae} and Kim, {Soo Joong} and Jin, {Dong Kyu} and Cho, {Jin Man} and Kim, {Byung Ok} and Kim, {Sang Wook} and Kim, {Jeong Kyung} and Kim, {Tae Ik} and Nah, {Deug Young} and Park, {Si Hoon} and Lee, {Sang Hyun} and Lee, {Seung Uk} and Chung, {Hang Jae} and Cho, {Jang Hyun} and Jin, {Seung Won} and Jang, {Yang Soo} and Cho, {Jeong Gwan} and Park, {Seung Jung}",
year = "2014",
month = jan,
day = "1",
doi = "10.3349/ymj.2014.55.1.132",
language = "English",
volume = "55",
pages = "132--140",
journal = "Yonsei medical journal",
issn = "0513-5796",
publisher = "Yonsei University College of Medicine",
number = "1",
}