Comparison of the intraparenchymal biocompatibility of oxidized regenerated cellulose and porcine small intestine submucosa in rat kidney

Purpose: The objective of this study was to evaluate the biological properties of a variety of materials that could be used in partial nephrectomy. Materials and Methods: 54 Sprague-Dawley rats (9 for each group) divided into an experimental period of 4 and 12 weeks, respectively. 2 other groups were the negative control for this experiment. We inserted oxidized regenerated cellulose and porcine small intestine submucosa into the defected renal parenchyme in the experimental groups. At the end of the observation periods, the animals were killed and their specimens prepared for histological examination to evaluate the different materials biocompatibility. Results: The reaction of the tissue to the materials diminished with time. After analyzing both periods, the inflammatory reactions to oxidized regenerated cellulose and porcine small intestine submucosa were considered slight. There were no significant differences between oxidized regenerated cellulose and porcine small intestine submucosa. Oxidized regenerated cellulose and porcine small intestine submucosa showed biocompatibility in this test model at both time periods. Conclusions: It was concluded that there was no difference of biocompatibility between oxidized regenerated cellulose and porcine small intestine submucosa. Both materials are safe, biocompatible materials that can be inserted into the renal parenchyma.