Comparison of Neoatherosclerosis and Neovascularization between Patients with and Without Diabetes An Optical Coherence Tomography Study

Lei Gao, Seung Jung Park, Yangsoo Jang, Stephen Lee, Chong Jin Kim, Yoshiyasu Minami, Daniel Ong, Tsunenari Soeda, Rocco Vergallo, Hang Lee, Bo Yu, Shiro Uemura, Ik Kyung Jang

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18 Citations (Scopus)


Objectives This study aimed to investigate the characteristics of neoatherosclerosis (NA) in patients with diabetes mellitus (DM) after drug-eluting stent (DES) implantation using optical coherence tomography. Background NA is an important substrate for stent failure. In vivo NA characteristics in DM patients have not been investigated. Methods A total of 397 patients with 452 DES who underwent follow-up optical coherence tomography examination after DES implantation were enrolled. Characteristics of NA were compared between DM and non-DM patients. Neovascularization was defined as signal-poor holes or tubular structures with a diameter of 50 to 300 μm. Results A total of 123 DES with NA lesions in 115 patients were identified. The incidence of NA was similar between DM and non-DM patients (29.6% vs. 28.6%; p = 0.825). Compared with the non-DM group, neovascularization was more frequently observed in the DM group (55.1% vs. 32.4%; p = 0.012). The multivariate logistic model demonstrated that DM (odds ratio: 3.00; 95% confidence interval: 1.31 to 6.81; p = 0.009) and follow-up duration (odds ratio: 1.03; 95% confidence interval: 1.02 to 1.05; p < 0.001) were the independent predictors for neovascularization in NA lesions. DM patients with glycated hemoglobin ≥7.0% had a higher prevalence of thin-cap fibroatheroma compared with those with glycated hemoglobin <7.0% (40.0% vs. 8.3%; p = 0.01). Conclusions The incidence of NA was similar between patients with and without DM. Neovascularization in NA lesions was more frequent in those with DM. Poorly controlled DM patients had a higher incidence of thin-cap fibroatheroma, compared with those with well-controlled DM.

Original languageEnglish
Pages (from-to)1044-1052
Number of pages9
JournalJACC: Cardiovascular Interventions
Issue number8
Publication statusPublished - 2015 Jul 1

Bibliographical note

Publisher Copyright:
© 2015 American College of Cardiology Foundation.

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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