Comparative study of pulpal responses to ProRoot MTA, Vitapex, and Metapex in canine teeth

Woojin Kwon, Ik Hwan Kim, Chung Min Kang, Byurira Kim, Yooseok Shin, Je Seon Song

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Background/purpose: ProRoot MTA, Vitapex, and Metapex are widely used for pulp treatment of primary tooth. The aim of this study was to compare the pulpal responses to ProRoot MTA, Vitapex, and Metapex in a canine model of pulpotomy. Materials and methods: Pulpotomy procedure was performed to 34 teeth (21 incisors and 13 premolars) and ProRoot MTA, Vitapex or Metapex was applicated to artificially exposed pulp tissues. After 13 weeks, the teeth were extracted and processed with hematoxylin-eosin staining for histologic evaluation. All specimens were evaluated in several categorys related to calcific barrier, inflammatory responses and the area of calcific barrier formation was measured. Results: Most of the specimens in the ProRoot MTA group developed a calcific barrier at the pulp amputation site and showed a low level of inflammatory response. However, in comparison to ProRoot MTA group, a small amount of calcific barrier formed in Vitapex and Metapex groups. Conclusion: This in vivo study found that Vitapex and Metapex induced similar pulpal responses but showed poor outcomes compared with using ProRoot MTA. Vitapex and Metapex are therefore not good substitutes for ProRoot MTA in direct pulp capping and pulpotomy.

Original languageEnglish
Pages (from-to)1274-1280
Number of pages7
JournalJournal of Dental Sciences
Issue number4
Publication statusPublished - 2021 Oct

Bibliographical note

Funding Information:
Woojin Kwon and Ik-Hwan Kim contributed equally to this work. This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF- 2018R1A1A1A05018328 ) and the Ministry of Education ( 2018R1D1A1B07041657 ).

Publisher Copyright:
© 2021 Association for Dental Sciences of the Republic of China

All Science Journal Classification (ASJC) codes

  • Dentistry(all)


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