Combination therapy of oral hypoglycemic agents in patients with type 2 diabetes mellitus

Min Kyong Moon, Kyu Yeon Hur, Seung Hyun Ko, Seok O. Park, Byung Wan Lee, Jin Hwa Kim, Sang Youl Rhee, Hyun Jin Kim, Kyung Mook Choi, Nan Hee Kim

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)


The Korean Diabetes Association (KDA) recently updated the Clinical Practice Guidelines on antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus (T2DM). In combination therapy of oral hypoglycemic agents (OHAs), general recommendations were not changed from those of the 2015 KDA guidelines. The Committee on Clinical Practice Guidelines of the KDA has extensively reviewed and discussed the results of meta-analyses and systematic reviews of effectiveness and safety of OHAs and many clinical trials on Korean patients with T2DM for the update of guidelines. All OHAs were effective when added to metformin or metformin and sulfonylurea, although the effects of each agent on body weight and hypoglycemia were different. Therefore, selection of a second agent as a metformin add-on therapy or third agent as a metformin and sulfonylurea add-on therapy should be based on the patient’s clinical characteristics and the efficacy, side effects, mechanism of action, risk of hypoglycemia, effect on body weight, patient preference, and combined comorbidity. In this review, we address the results of meta-analyses and systematic reviews, comparing the effectiveness and safety among OHAs. It will help to choose the appropriate drug for an individual patient with T2DM.

Original languageEnglish
Pages (from-to)974-983
Number of pages10
JournalKorean Journal of Internal Medicine
Issue number6
Publication statusPublished - 2017 Nov

Bibliographical note

Publisher Copyright:
© 2017 The Korean Association of Internal Medicine

All Science Journal Classification (ASJC) codes

  • Internal Medicine


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