Clinicopathological and prognostic significance of programmed death ligand 1 expression in Korean patients with triple-negative breast carcinoma

Hyun Soo Kim, Sung Im Do, Dong Hoon Kim, Sophia Apple

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Background/Aim: The clinicopathological and prognostic significances of programmed death ligand 1 (PDL1) expression in triple-negative breast carcinoma (TNBC) are still unclear. We investigated whether PD-L1 expression is associated with clinicopathological characteristics and outcomes of TNBC patients. Materials and Methods: We performed immunostaining for PD-L1 (SP142) in 83 TNBCs. Staining proportion of =1% was regarded as positive PD-L1 expression. Results: Positive intratumoral (IT) PD-L1 expression (19/83; 22.9%) was inversely associated with lymphovascular invasion (LVI) and distant metastasis, and was significantly associated with better disease-free survival for TNBC patients. Positive stromal PD-L1 expression (44/83; 53.0%) also correlated inversely with LVI. Conclusion: Positive IT PD-L1 expression was associated with favorable outcomes in TNBC. In addition, positive IT and stromal PD-L1 were inversely associated with LVI and distant metastasis of TNBC.

Original languageEnglish
Pages (from-to)1487-1494
Number of pages8
JournalAnticancer research
Volume40
Issue number3
DOIs
Publication statusPublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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