TY - JOUR
T1 - Clinical utility of novel biomarkers in the prediction of coronary heart disease
AU - Kim, Hyeon Chang
PY - 2012/4
Y1 - 2012/4
N2 - Coronary heart disease (CHD) is a significant cause of morbidity and mortality worldwide. Many risk prediction models have been developed in an effort to assist clinicians in risk assessment and the prevention of CHD. However, it is unclear whether the existing CHD prediction tools can improve clinical performance, and recently, there has been a lot of effort being made to improve the accuracy of the prediction models. A large number of novel biomarkers have been identified to be associated with cardiovascular risk, and studied with the goal of improving the accuracy and clinical utility of CHD risk prediction. Yet, controversy still remains with regard to the utility of novel biomarkers in CHD risk assessment, and in finding the best statistical methods to assess the incremental value of the biomarkers. This article discusses the statistical approaches that can be used to evaluate the predictive values of new biomarkers, and reviews the clinical utility of novel biomarkers in CHD prediction, specifically in the Korean population.
AB - Coronary heart disease (CHD) is a significant cause of morbidity and mortality worldwide. Many risk prediction models have been developed in an effort to assist clinicians in risk assessment and the prevention of CHD. However, it is unclear whether the existing CHD prediction tools can improve clinical performance, and recently, there has been a lot of effort being made to improve the accuracy of the prediction models. A large number of novel biomarkers have been identified to be associated with cardiovascular risk, and studied with the goal of improving the accuracy and clinical utility of CHD risk prediction. Yet, controversy still remains with regard to the utility of novel biomarkers in CHD risk assessment, and in finding the best statistical methods to assess the incremental value of the biomarkers. This article discusses the statistical approaches that can be used to evaluate the predictive values of new biomarkers, and reviews the clinical utility of novel biomarkers in CHD prediction, specifically in the Korean population.
KW - Biomarkers
KW - Coronary heart disease
KW - Prevention
KW - Risk assessment
UR - http://www.scopus.com/inward/record.url?scp=84861084735&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861084735&partnerID=8YFLogxK
U2 - 10.4070/kcj.2012.42.4.223
DO - 10.4070/kcj.2012.42.4.223
M3 - Review article
C2 - 22563333
AN - SCOPUS:84861084735
SN - 1738-5520
VL - 42
SP - 223
EP - 228
JO - Korean Circulation Journal
JF - Korean Circulation Journal
IS - 4
ER -