Clinical study of Zalsming(®) on xerosis and pruritus

Background: Xerosis is a relatively common disorder, especially in the elderly. The condition is characterized by fine scaling and is associated with generalized pruritus. Objective: The purpose of this study was to evaluate the clinical efficacy, safety and tolerability of Zalsming(®) cream in patients with xerosis and pruritus. Methods: Thirty patients were treated with Zalsming(®) cream. Clinical efficacy, as measured by the score of subjective symptom and objective signs, transepidermal water loss(TEWL) and electron microscopic finding, were assessed at 2, 4, and 6 weeks after topical application of the cream. Results: The scores of clinical signs and TEWL showed statistically significant improvements. No one developed any local or systemic side effects. Conclusion: Topical application of Zalsming(®) cream was found to be effective and safe for patients suffering from xerosis and pruritus.