Clinical implication of highly sensitive detection of the BRAFV600E mutation in fine-needle aspirations according to the thyroid bethesda system in patients with conventional papillary thyroid carcinoma

Jae Young Seo; Jong Rak Choi; Hee Jung Moon; Eun Kyung Kim; Kyung Hwa Han; Hyunki Kim; Jin Young Kwak

doi:10.1177/0003489414560433

Clinical implication of highly sensitive detection of the BRAF^V600E mutation in fine-needle aspirations according to the thyroid bethesda system in patients with conventional papillary thyroid carcinoma

Jae Young Seo, Jong Rak Choi, Hee Jung Moon, Eun Kyung Kim, Kyung Hwa Han, Hyunki Kim, Jin Young Kwak

Department of Radiology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Background: We investigated the additional diagnostic yield of the mutation test and evaluated the frequency of the BRAF mutation in conventional PTC (cPTC) according to ultrasound (US) features and the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on the BRAF^V600E mutation status. Materials and Methods: During the study period, 279 patients who underwent FNA with an additional BRAF^V600E mutation test were diagnosed as cPTC after surgery. We analyzed the association between the mutation and several clinical factors. Results: Of the 279 cPTCs, 250 (89.6%) had the BRAF^V600E mutation. The BRAF mutation test was helpful in diagnosing an additional 19% (53/279) of cPTCs. The frequency of the BRAF mutation in cPTCs with suspicious US features was higher than that of cPTCs with negative US features regardless of the BSRTC. Conclusions: Suspicious US features may be helpful in deciding whether an additional BRAF^V600E mutation test should be done in thyroid nodules with indeterminate cytology.

Original language	English
Pages (from-to)	392-399
Number of pages	8
Journal	Annals of Otology, Rhinology and Laryngology
Volume	124
Issue number	5
DOIs	https://doi.org/10.1177/0003489414560433
Publication status	Published - 2015 May 1

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education (2013R1A1A2058817).

Publisher Copyright:
© 2014 The Author(s).

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

Access to Document

10.1177/0003489414560433

Cite this

Seo, J. Y., Choi, J. R., Moon, H. J., Kim, E. K., Han, K. H., Kim, H., & Kwak, J. Y. (2015). Clinical implication of highly sensitive detection of the BRAF^V600E mutation in fine-needle aspirations according to the thyroid bethesda system in patients with conventional papillary thyroid carcinoma. Annals of Otology, Rhinology and Laryngology, 124(5), 392-399. https://doi.org/10.1177/0003489414560433

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abstract = "Background: We investigated the additional diagnostic yield of the mutation test and evaluated the frequency of the BRAF mutation in conventional PTC (cPTC) according to ultrasound (US) features and the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on the BRAFV600E mutation status. Materials and Methods: During the study period, 279 patients who underwent FNA with an additional BRAFV600E mutation test were diagnosed as cPTC after surgery. We analyzed the association between the mutation and several clinical factors. Results: Of the 279 cPTCs, 250 (89.6%) had the BRAFV600E mutation. The BRAF mutation test was helpful in diagnosing an additional 19% (53/279) of cPTCs. The frequency of the BRAF mutation in cPTCs with suspicious US features was higher than that of cPTCs with negative US features regardless of the BSRTC. Conclusions: Suspicious US features may be helpful in deciding whether an additional BRAFV600E mutation test should be done in thyroid nodules with indeterminate cytology.",

author = "Seo, {Jae Young} and Choi, {Jong Rak} and Moon, {Hee Jung} and Kim, {Eun Kyung} and Han, {Kyung Hwa} and Hyunki Kim and Kwak, {Jin Young}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education (2013R1A1A2058817). Publisher Copyright: {\textcopyright} 2014 The Author(s).",

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Seo, JY, Choi, JR, Moon, HJ, Kim, EK, Han, KH, Kim, H & Kwak, JY 2015, 'Clinical implication of highly sensitive detection of the BRAF^V600E mutation in fine-needle aspirations according to the thyroid bethesda system in patients with conventional papillary thyroid carcinoma', Annals of Otology, Rhinology and Laryngology, vol. 124, no. 5, pp. 392-399. https://doi.org/10.1177/0003489414560433

Clinical implication of highly sensitive detection of the BRAF^V600E mutation in fine-needle aspirations according to the thyroid bethesda system in patients with conventional papillary thyroid carcinoma. / Seo, Jae Young; Choi, Jong Rak; Moon, Hee Jung et al.
In: Annals of Otology, Rhinology and Laryngology, Vol. 124, No. 5, 01.05.2015, p. 392-399.

Research output: Contribution to journal › Article › peer-review

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AU - Choi, Jong Rak

AU - Moon, Hee Jung

AU - Kim, Eun Kyung

AU - Han, Kyung Hwa

AU - Kim, Hyunki

AU - Kwak, Jin Young

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education (2013R1A1A2058817). Publisher Copyright: © 2014 The Author(s).

PY - 2015/5/1

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N2 - Background: We investigated the additional diagnostic yield of the mutation test and evaluated the frequency of the BRAF mutation in conventional PTC (cPTC) according to ultrasound (US) features and the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on the BRAFV600E mutation status. Materials and Methods: During the study period, 279 patients who underwent FNA with an additional BRAFV600E mutation test were diagnosed as cPTC after surgery. We analyzed the association between the mutation and several clinical factors. Results: Of the 279 cPTCs, 250 (89.6%) had the BRAFV600E mutation. The BRAF mutation test was helpful in diagnosing an additional 19% (53/279) of cPTCs. The frequency of the BRAF mutation in cPTCs with suspicious US features was higher than that of cPTCs with negative US features regardless of the BSRTC. Conclusions: Suspicious US features may be helpful in deciding whether an additional BRAFV600E mutation test should be done in thyroid nodules with indeterminate cytology.

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