Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients

S. Y. Jang, S. Y. Lee, E. J. Lee, J. S. Yoon

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19 Citations (Scopus)


AimTo compare clinical characteristics and thyroid-stimulating hormone receptor antibodies (TRAbs) in thyroid-associated ophthalmopathy (TAO) in euthyroid Korean patients with those in hyperthyroid patients.MethodsClinical activity scores (CASs), modified NOSPECS scores, exophthalmometry values, prevalence of optic neuropathy, restrictive myopathy and lid retraction, and the positivity and levels of TRAb (thyrotropin-binding inhibitor immunoglobulin (TBII) and thyroid-stimulating immunoglobulin (TSI)) were compared in 24 euthyroid (group A) and 139 clinical/subclinical hyperthyroid TAO patients (group B).ResultsGroup A presented more clinically unilateral involvement than group B (79.2% vs 27.3%, P0.001), less active (CAS 1.50 vs 2.26, P0.014) and less severe clinical course (NOSPECS 3.38 vs 4.13, P0.037). Lid retraction was more prevalent in group A than group B (91.7% vs 66.2%, P0.014). Prevalence of optic neuropathy and restrictive myopathy, and the mean value of exophthalmometry were not different. Mean TBII levels were lower (7.20 IU/l) in group A than in group B (44.58 IU/l, P0.001). A similar difference was found in the TSI bioassay (201.40% vs 425.19%, P0.001). The positive rate of TBII in group A (34.8%) was significantly lower than in group B (90.8%, P0.001). The positive rate of TSI was high in both group A (83.3%) and B (91.7%), with no significant difference (P0.337).ConclusionsPatients with euthyroid TAO showed a less active and severe clinical course, more unilateral involvement, and lower levels of TRAb than those in patients with hyperthyroid TAO. These distinct clinical and biochemical characteristics might be useful in assessment of euthyroid TAO, and the TSI might be more sensitive for diagnosing these patients.

Original languageEnglish
Pages (from-to)1263-1269
Number of pages7
JournalEye (Basingstoke)
Issue number9
Publication statusPublished - 2012 Sept

Bibliographical note

Funding Information:
This study was supported by a grant from the College of Medicine, Yonsei University (6-2010-0051).

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems


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