Clinical characteristics and outcome for hepatitis C virus-positive diffuse large B-cell lymphoma

Byeong Bae Park, Jin Seok Kim, Young Yuel Lee, Hye Jin Kang, Baek Yeol Ryoo, Jung Hun Kang, Ho Young Kim, Bong Seog Kim, Sung Yong Oh, Hyuk Chan Kwon, Jong Ho Won, Kihyun Kim, Keunchil Park, Cheolwon Suh, Won Seog Kim

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18 Citations (Scopus)


Several previous studies have addressed the association between hepatitis C virus (HCV) infection and non-Hodgkin lymphoma (NHL), but there are few studies on HCV-related diffuse large B-cell lymphoma (DLBL). We conducted this retrospective study to investigate the distinctive clinical characteristics and outcome for HCV-positive DLBL. We compared the clinical characteristics and outcomes of 32 HCV-positive DLBL cases from nine Korean institutions with those of 371 HCV-negative DLBL cases. A higher percentage of HCV-positive DLBL cases were associated with old age (≥60) than HCV-negative DLBL cases at diagnosis (59.4% vs. 36.1%, respectively, P=0.009) and HCV-positive cases were less likely than HCV-negative cases to have extranodal involvement (53.1% vs. 71.1%, respectively, P=0.044). The nodal presentation was the only independent factor favorably influencing the event free survival (EFS) in HCV-positive DLBL (HR=0.11, 95% CI; 0.01-0.95, P=0.012). In comparison to patients with HCV-negative DLBL, HCV-positive DLBL patients had a superior complete response rate (P=0.023) and EFS (P=0.02). In Korean patients, HCV-positive DLBL is more common with old age and has less extranodal involvement than does HCV-negative DLBL. The superior survival outcome for HCV-positive DLBL should be verified by further investigation, especially with respect to its correlation with transformed low-grade NHL.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalLeukemia and Lymphoma
Issue number1
Publication statusPublished - 2008 Jan

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research


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