Clinical assessment of oral malodor using autofluorescence of tongue coating

Eun Song Lee, Hyun Kyung Yim, Hyung Suk Lee, Jong Hoon Choi, Ji Hyun Lee, Baek Il Kim

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Objectives: The aim of this study was to evaluate whether a new method using quantitative light-induced fluorescence-digital (QLF-D) was appropriate for the diagnosis of oral malodor by quantifying the fluorescence of tongue coating. Methods: This study examined 103 healthy subjects who have an oral malodor as a main complaint. The levels of oral malodor were measured by organoleptic scores (OLS) and volatile sulfur compound (VSC) levels. The fluorescent tongue coating images captured by QLF-D were quantified as the integrated fluorescence score (IF score) by multiplying the intensity and area of fluorescence. The correlations between the fluorescence parameters and OLS as well as VSC levels and the diagnostic accuracy of the IF score were evaluated. Results: The IF score of tongue coating showed a significant positive correlation with the OLS (r = 0.54, p < 0.01) and the VSC levels (r = 0.49, p < 0.01). This score was significantly differed with the level of oral malodor (p < 0.001), and its AUC was 0.72 in identifying the patient with definite oral malodor (≥OLS 2). Conclusions: A new method quantifying tongue coating fluorescence detected by QLF-D can be used to diagnose oral malodor and assess its severity in the clinical practice.

Original languageEnglish
Pages (from-to)323-329
Number of pages7
JournalPhotodiagnosis and Photodynamic Therapy
Publication statusPublished - 2016 Mar 1

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2013R1A1A2062505 ) and the Yonsei University Future-leading Research Initiative of 2014(2014-22-0171).

Publisher Copyright:
© 2015 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Oncology
  • Dermatology
  • Pharmacology (medical)


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