Clinical and pathological significance of Orai1 channel expression in human diabetic nephropathy

Yooujin Kwak, Jun Young Lee, Jae Seok Kim, Jae Won Yang, Kyu Hee Hwang, Seung Kuy Cha, Minseob Eom

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Targeted therapies for diabetic nephropathy (DN) are lacking, partly due to their irreversible nature. The role of Orai1, a store-operated Ca2+ channel, in DN remains debated, with conflicting evidence on its effect on proteinuria in animal models. We aimed to elucidate the functional relevance of Orai1 expression for clinicopathological parameters in patients with DN. Methods: In this study, we included 93 patients diagnosed with DN between 2009 and 2019. Immunohistochemical staining for Orai1 was performed on paraffin-embedded kidney sections. The significance of Orai1 expression in human DN was assessed by ex-amining its correlation with DN’s pathological and clinical parameters using Pearson’s correlation coefficient and univariate logistic regression. Results: Orai1 was significantly overexpressed in DN patients compared to control. A strong correlation was observed between increased Orai1 expression and higher Renal Pathology Society DN classification, enhanced interstitial fibrosis and tubular atrophy scores. Positive correlations with serum creatinine levels and prognosis of chronic kidney disease (CKD) by glomerular filtration rate (GFR) and albuminuria category were noted but the estimated GFR was inversely related to Orai1 expression. Orai1’s association with advanced CKD stages persisted even after adjusting for confounding variables in multivariate logistic regression analysis. Conclusion: Orai1 expression is closely associated with histological and clinical severities of DN, suggesting its potential as a predic-tive biomarker for disease progression and prognosis. These findings provide new perspectives on therapeutic interventions targeting Orai1 in DN.

Original languageEnglish
Pages (from-to)626-634
Number of pages9
JournalKidney Research and Clinical Practice
Volume43
Issue number5
DOIs
Publication statusPublished - 2024 Sept 1

Bibliographical note

Publisher Copyright:
© 2024 by The Korean Society of Nephrology.

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

Fingerprint

Dive into the research topics of 'Clinical and pathological significance of Orai1 channel expression in human diabetic nephropathy'. Together they form a unique fingerprint.

Cite this