Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion

Seung Sik Rho, Hyun Jung Choi, Jeong Ki Min, Heon Woo Lee, Hongryeol Park, Hyojin Park, Young Myeong Kim, Young Guen Kwon

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell-cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell-cell adhesion and angiogenesis.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - 2011 Jan 7

Bibliographical note

Funding Information:
This work was supported by a National Research Laboratory Grant (20100018854) and the Korea Biotech R&D Group of Next-generation growth engine project (2010K0012733-08A0301-00310) from the Ministry of Education and Science Technology, and a grant from the Korea Health 21 R&D Project, Ministry of Health Welfare & Family Affairs (A085136), Korea.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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