Cis-2-Aminocyclohex-4-enecarboxylic acid as a new building block of helical foldamers

Sunmi Kwon; Philjae Kang; Moon Gun Choi; Soo Hyuk Choi

doi:10.1039/c4nj02056a

Cis-2-Aminocyclohex-4-enecarboxylic acid as a new building block of helical foldamers

Sunmi Kwon, Philjae Kang, Moon Gun Choi, Soo Hyuk Choi

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

cis-2-Aminocyclohex-4-enecarboxylic acid (cis-ACHE) is a conformationally constrained β-amino acid. We showed that the conformational preference of a cis-ACHE residue is similar to that of cis-2-aminocyclohexanecarboxylic acid. α/β-Peptides that consist of the alternation of (1S,2R)-cis-ACHE and l-alanine adopted 11/9-helical conformations in solution and in the crystal state.

Original language	English
Pages (from-to)	3221-3224
Number of pages	4
Journal	New Journal of Chemistry
Volume	39
Issue number	5
DOIs	https://doi.org/10.1039/c4nj02056a
Publication status	Published - 2015 May 1

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2015.

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Materials Chemistry

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abstract = "cis-2-Aminocyclohex-4-enecarboxylic acid (cis-ACHE) is a conformationally constrained β-amino acid. We showed that the conformational preference of a cis-ACHE residue is similar to that of cis-2-aminocyclohexanecarboxylic acid. α/β-Peptides that consist of the alternation of (1S,2R)-cis-ACHE and l-alanine adopted 11/9-helical conformations in solution and in the crystal state.",

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AU - Kwon, Sunmi

AU - Kang, Philjae

AU - Choi, Moon Gun

AU - Choi, Soo Hyuk

PY - 2015/5/1

Y1 - 2015/5/1

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AB - cis-2-Aminocyclohex-4-enecarboxylic acid (cis-ACHE) is a conformationally constrained β-amino acid. We showed that the conformational preference of a cis-ACHE residue is similar to that of cis-2-aminocyclohexanecarboxylic acid. α/β-Peptides that consist of the alternation of (1S,2R)-cis-ACHE and l-alanine adopted 11/9-helical conformations in solution and in the crystal state.

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Cis-2-Aminocyclohex-4-enecarboxylic acid as a new building block of helical foldamers

Abstract

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