Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1

Sujin Lee; Sony Maharjan; Kyeojin Kim; Nam Jung Kim; Hyun Jung Choi; Young Guen Kwon; Young Ger Suh

doi:10.1016/j.bmcl.2010.09.071

Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1

Sujin Lee, Sony Maharjan, Kyeojin Kim, Nam Jung Kim, Hyun Jung Choi, Young Guen Kwon, Young Ger Suh

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Design and synthesis of cholesterol-derived anti-apoptotic agents were described. The synthesized cholesterol analogs designed on the structural basis of ginsenoside Rk1 inhibited the undesirable apoptosis of human endothelial cells, which are induced by a vascular injury. In particular, analogue 1 possessing 4,6-di-O-acetyl-2,3-dideoxyhex-2-enopyran linked to hydroxyl group of cholesterol exhibited the most effective anti-apoptotic activities at both 5 and 10 μg/ml.

Original language	English
Pages (from-to)	7102-7105
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2010.09.071
Publication status	Published - 2010 Dec 1

Bibliographical note

Funding Information:
This work is supported by a grant from the Korea Health 21 R&D Project, Ministry of Health Welfare & Family Affairs (A085136), Korea.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2010.09.071

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abstract = "Design and synthesis of cholesterol-derived anti-apoptotic agents were described. The synthesized cholesterol analogs designed on the structural basis of ginsenoside Rk1 inhibited the undesirable apoptosis of human endothelial cells, which are induced by a vascular injury. In particular, analogue 1 possessing 4,6-di-O-acetyl-2,3-dideoxyhex-2-enopyran linked to hydroxyl group of cholesterol exhibited the most effective anti-apoptotic activities at both 5 and 10 μg/ml.",

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AU - Lee, Sujin

AU - Maharjan, Sony

AU - Kim, Kyeojin

AU - Kim, Nam Jung

AU - Choi, Hyun Jung

AU - Kwon, Young Guen

AU - Suh, Young Ger

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Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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