Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1

Sujin Lee, Sony Maharjan, Kyeojin Kim, Nam Jung Kim, Hyun Jung Choi, Young Guen Kwon, Young Ger Suh

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8 Citations (Scopus)


Design and synthesis of cholesterol-derived anti-apoptotic agents were described. The synthesized cholesterol analogs designed on the structural basis of ginsenoside Rk1 inhibited the undesirable apoptosis of human endothelial cells, which are induced by a vascular injury. In particular, analogue 1 possessing 4,6-di-O-acetyl-2,3-dideoxyhex-2-enopyran linked to hydroxyl group of cholesterol exhibited the most effective anti-apoptotic activities at both 5 and 10 μg/ml.

Original languageEnglish
Pages (from-to)7102-7105
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number23
Publication statusPublished - 2010 Dec 1

Bibliographical note

Funding Information:
This work is supported by a grant from the Korea Health 21 R&D Project, Ministry of Health Welfare & Family Affairs (A085136), Korea.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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