Chemically and Biologically Engineered Bacteria-Based Delivery Systems for Emerging Diagnosis and Advanced Therapy

Zhaoting Li, Yixin Wang, Jun Liu, Piper Rawding, Jiyoon Bu, Seungpyo Hong, Quanyin Hu

Research output: Contribution to journalReview articlepeer-review

102 Citations (Scopus)

Abstract

Bacteria are one of the main groups of organisms, which dynamically and closely participate in human health and disease development. With the integration of chemical biotechnology, bacteria have been utilized as an emerging delivery system for various biomedical applications. Given the unique features of bacteria such as their intrinsic biocompatibility and motility, bacteria-based delivery systems have drawn wide interest in the diagnosis and treatment of various diseases, including cancer, infectious diseases, kidney failure, and hyperammonemia. Notably, at the interface of chemical biotechnology and bacteria, many research opportunities have been initiated, opening a promising frontier in biomedical application. Herein, the current synergy of chemical biotechnology and bacteria, the design principles for bacteria-based delivery systems, the microbial modulation, and the clinical translation are reviewed, with a special focus on the emerging advances in diagnosis and therapy.

Original languageEnglish
Article number2102580
JournalAdvanced Materials
Volume33
Issue number38
DOIs
Publication statusPublished - 2021 Sept 23

Bibliographical note

Publisher Copyright:
© 2021 Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering

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