Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities

Chau Van Minh, Nguyen Xuan Nhiem, Hoang Thi Yen, Phan Van Kiem, Bui Huu Tai, Hoang Le Tuan Anh, Truong Thi Thu Hien, Seon Ju Park, Nanyoung Kim, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Abstract One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-β-D-glucopyranoside (5), chrysoeriol-7- O-β-D-glucopyranoside (6), 10α-cucurbita-5,24-dien-3β-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 μM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 μM.

Original languageEnglish
Article number490
Pages (from-to)1443-1448
Number of pages6
JournalArchives of pharmacal research
Issue number8
Publication statusPublished - 2015 Aug 8

Bibliographical note

Publisher Copyright:
© 2015 The Pharmaceutical Society of Korea.

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities'. Together they form a unique fingerprint.

Cite this