Chemical constituents of alnus firma and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia

Min A. Lee; Hee Kyoung Lee; Seung Hyun Kim; Young Choong Kim; Sang Hyun Sung

doi:10.1055/s-0029-1240911

Chemical constituents of alnus firma and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia

Min A. Lee, Hee Kyoung Lee, Seung Hyun Kim, Young Choong Kim, Sang Hyun Sung

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

A methanolic extract of Alnus firma barks (Betulaceae) significantly attenuated nitric oxide production in lipopolysaccharide-stimulated BV2 microglia. Two new compounds, characterized as 4-hydroxy-2,6-dimethoxyphenyl 6-O-syringoyl-β-D-glucopyranoside (1) and 4-hydroxy-2,6-dimethoxyphenyl 6-O-vanilloyl-β-D-glucopyranoside (2), were isolated from the barks of A. firma using bioactivity-guided fractionation, together with two known phenolic glycosides (3, 4) and 11 known diarylheptanoids (515). Among these compounds, 14 and 611 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 10μ M to 100μ M.

Original language	English
Pages (from-to)	1007-1010
Number of pages	4
Journal	Planta Medica
Volume	76
Issue number	10
DOIs	https://doi.org/10.1055/s-0029-1240911
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "A methanolic extract of Alnus firma barks (Betulaceae) significantly attenuated nitric oxide production in lipopolysaccharide-stimulated BV2 microglia. Two new compounds, characterized as 4-hydroxy-2,6-dimethoxyphenyl 6-O-syringoyl-β-D-glucopyranoside (1) and 4-hydroxy-2,6-dimethoxyphenyl 6-O-vanilloyl-β-D-glucopyranoside (2), were isolated from the barks of A. firma using bioactivity-guided fractionation, together with two known phenolic glycosides (3, 4) and 11 known diarylheptanoids (515). Among these compounds, 14 and 611 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 10μ M to 100μ M.",

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AU - Lee, Hee Kyoung

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AU - Kim, Young Choong

AU - Sung, Sang Hyun

PY - 2010

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Chemical constituents of alnus firma and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia

Abstract

All Science Journal Classification (ASJC) codes

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