Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro

Seung Hyun Kim; Mi Kyeong Lee; Ki Yong Lee; Sang Hyun Sung; Jinwoong Kim; Young Choong Kim

doi:10.1080/14756360802667977

Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro

Seung Hyun Kim, Mi Kyeong Lee, Ki Yong Lee, Sang Hyun Sung, Jinwoong Kim, Young Choong Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H₂O₂. Seven monoterpenes, paeonilactone-B (1), paeonilactone-C (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. Among them, compounds 2 and 4 significantly protected primary cultures of rat cortical cells against H₂O₂-induced neurotoxicity.

Original language	English
Pages (from-to)	1138-1140
Number of pages	3
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	24
Issue number	5
DOIs	https://doi.org/10.1080/14756360802667977
Publication status	Published - 2009 Oct

Bibliographical note

Funding Information:
This research was supported by a grant PF06200-00 from Plant Diversity Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Korea.

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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10.1080/14756360802667977

Cite this

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title = "Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro",

abstract = "The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H2O2. Seven monoterpenes, paeonilactone-B (1), paeonilactone-C (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. Among them, compounds 2 and 4 significantly protected primary cultures of rat cortical cells against H2O2-induced neurotoxicity.",

author = "Kim, {Seung Hyun} and Lee, {Mi Kyeong} and Lee, {Ki Yong} and Sung, {Sang Hyun} and Jinwoong Kim and Kim, {Young Choong}",

note = "Funding Information: This research was supported by a grant PF06200-00 from Plant Diversity Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Korea.",

year = "2009",

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doi = "10.1080/14756360802667977",

language = "English",

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AU - Kim, Seung Hyun

AU - Lee, Mi Kyeong

AU - Lee, Ki Yong

AU - Sung, Sang Hyun

AU - Kim, Jinwoong

AU - Kim, Young Choong

N1 - Funding Information: This research was supported by a grant PF06200-00 from Plant Diversity Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Korea.

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AB - The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H2O2. Seven monoterpenes, paeonilactone-B (1), paeonilactone-C (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. Among them, compounds 2 and 4 significantly protected primary cultures of rat cortical cells against H2O2-induced neurotoxicity.

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Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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