Chemical constituents from the fruits of Schisandra sphenanthera and their cytotoxicity activity

Hee Jae Kwak; Seon Ju Park; Guijae Yoo; Jun Hyung Park; Youngse Oh; Mira Oh; Nguyen Xuan Nhiem; Yun Na Kim; Eun Ju Jeong; Seung Hyun Kim

doi:10.1016/j.bjp.2019.05.006

Chemical constituents from the fruits of Schisandra sphenanthera and their cytotoxicity activity

Hee Jae Kwak, Seon Ju Park, Guijae Yoo, Jun Hyung Park, Youngse Oh, Mira Oh, Nguyen Xuan Nhiem, Yun Na Kim, Eun Ju Jeong, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Schisandra sphenanthera Rehder & E.H. Wilson, Schisandraceae, is well known as a type of traditional medicine for the treatment of hepatitis, diarrhea and insomnia in Asia. It was also reported to have antiviral and anti-HIV activities. Using various chromatographic resins and isolation techniques, a new lignan (1), erythro-4-(3,4-dimethoxyphenyl)-4-hydroxy-3-methylbutan-2yl-3,4-dimethoxybenzoate, along with fifteen known compounds, were isolated from fruits of S. sphenanthera. The structures of the compounds were identified by extensive spectroscopic and spectrometric methods including 1D and 2D NMR and MS data. All the isolated compounds were evaluated for their cytotoxicity activity against Hela, HepG2 and HCT-116 cells. Among them, compound schisanlactone C showed significant cytotoxicity activity.

Original language	English
Pages (from-to)	578-581
Number of pages	4
Journal	Revista Brasileira de Farmacognosia
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/j.bjp.2019.05.006
Publication status	Published - 2019 Sept 1

Bibliographical note

Funding Information:
This research was supported by a grant ( 16172MFD229 ) from Ministry of Food and Drug Safety in 2017.

Publisher Copyright:
© 2019 Sociedade Brasileira de Farmacognosia

All Science Journal Classification (ASJC) codes

Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/j.bjp.2019.05.006

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title = "Chemical constituents from the fruits of Schisandra sphenanthera and their cytotoxicity activity",

abstract = "Schisandra sphenanthera Rehder & E.H. Wilson, Schisandraceae, is well known as a type of traditional medicine for the treatment of hepatitis, diarrhea and insomnia in Asia. It was also reported to have antiviral and anti-HIV activities. Using various chromatographic resins and isolation techniques, a new lignan (1), erythro-4-(3,4-dimethoxyphenyl)-4-hydroxy-3-methylbutan-2yl-3,4-dimethoxybenzoate, along with fifteen known compounds, were isolated from fruits of S. sphenanthera. The structures of the compounds were identified by extensive spectroscopic and spectrometric methods including 1D and 2D NMR and MS data. All the isolated compounds were evaluated for their cytotoxicity activity against Hela, HepG2 and HCT-116 cells. Among them, compound schisanlactone C showed significant cytotoxicity activity.",

author = "Kwak, {Hee Jae} and Park, {Seon Ju} and Guijae Yoo and Park, {Jun Hyung} and Youngse Oh and Mira Oh and Nhiem, {Nguyen Xuan} and Kim, {Yun Na} and Jeong, {Eun Ju} and Kim, {Seung Hyun}",

note = "Funding Information: This research was supported by a grant ( 16172MFD229 ) from Ministry of Food and Drug Safety in 2017. Publisher Copyright: {\textcopyright} 2019 Sociedade Brasileira de Farmacognosia",

year = "2019",

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doi = "10.1016/j.bjp.2019.05.006",

language = "English",

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AU - Kwak, Hee Jae

AU - Park, Seon Ju

AU - Yoo, Guijae

AU - Park, Jun Hyung

AU - Oh, Youngse

AU - Oh, Mira

AU - Nhiem, Nguyen Xuan

AU - Kim, Yun Na

AU - Jeong, Eun Ju

AU - Kim, Seung Hyun

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Schisandra sphenanthera Rehder & E.H. Wilson, Schisandraceae, is well known as a type of traditional medicine for the treatment of hepatitis, diarrhea and insomnia in Asia. It was also reported to have antiviral and anti-HIV activities. Using various chromatographic resins and isolation techniques, a new lignan (1), erythro-4-(3,4-dimethoxyphenyl)-4-hydroxy-3-methylbutan-2yl-3,4-dimethoxybenzoate, along with fifteen known compounds, were isolated from fruits of S. sphenanthera. The structures of the compounds were identified by extensive spectroscopic and spectrometric methods including 1D and 2D NMR and MS data. All the isolated compounds were evaluated for their cytotoxicity activity against Hela, HepG2 and HCT-116 cells. Among them, compound schisanlactone C showed significant cytotoxicity activity.

AB - Schisandra sphenanthera Rehder & E.H. Wilson, Schisandraceae, is well known as a type of traditional medicine for the treatment of hepatitis, diarrhea and insomnia in Asia. It was also reported to have antiviral and anti-HIV activities. Using various chromatographic resins and isolation techniques, a new lignan (1), erythro-4-(3,4-dimethoxyphenyl)-4-hydroxy-3-methylbutan-2yl-3,4-dimethoxybenzoate, along with fifteen known compounds, were isolated from fruits of S. sphenanthera. The structures of the compounds were identified by extensive spectroscopic and spectrometric methods including 1D and 2D NMR and MS data. All the isolated compounds were evaluated for their cytotoxicity activity against Hela, HepG2 and HCT-116 cells. Among them, compound schisanlactone C showed significant cytotoxicity activity.

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Chemical constituents from the fruits of Schisandra sphenanthera and their cytotoxicity activity

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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