Chemical constituents from the fruits of Schisandra sphenanthera and their cytotoxicity activity

Hee Jae Kwak, Seon Ju Park, Guijae Yoo, Jun Hyung Park, Youngse Oh, Mira Oh, Nguyen Xuan Nhiem, Yun Na Kim, Eun Ju Jeong, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Schisandra sphenanthera Rehder & E.H. Wilson, Schisandraceae, is well known as a type of traditional medicine for the treatment of hepatitis, diarrhea and insomnia in Asia. It was also reported to have antiviral and anti-HIV activities. Using various chromatographic resins and isolation techniques, a new lignan (1), erythro-4-(3,4-dimethoxyphenyl)-4-hydroxy-3-methylbutan-2yl-3,4-dimethoxybenzoate, along with fifteen known compounds, were isolated from fruits of S. sphenanthera. The structures of the compounds were identified by extensive spectroscopic and spectrometric methods including 1D and 2D NMR and MS data. All the isolated compounds were evaluated for their cytotoxicity activity against Hela, HepG2 and HCT-116 cells. Among them, compound schisanlactone C showed significant cytotoxicity activity.

Original languageEnglish
Pages (from-to)578-581
Number of pages4
JournalRevista Brasileira de Farmacognosia
Issue number5
Publication statusPublished - 2019 Sept 1

Bibliographical note

Funding Information:
This research was supported by a grant ( 16172MFD229 ) from Ministry of Food and Drug Safety in 2017.

Publisher Copyright:
© 2019 Sociedade Brasileira de Farmacognosia

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)


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