TY - JOUR
T1 - Chemical Components of Ardisia splendens leaves and their activity against Coxsackie A16 viruses
AU - Van, Nguyen Thi Hong
AU - Vien, Trinh Anh
AU - Nhiem, Nguyen Xuan
AU - Van Kiem, Phan
AU - Van Minh, Chau
AU - Long, Pham Quoc
AU - Anh, Luu Tuan
AU - Cuong, Nguyen Manh
AU - Song, Jae Hyoung
AU - Ko, Hyun Jeong
AU - Kim, Nanyoung
AU - Parka, Seon Ju
AU - Kim, Seung Hyun
PY - 2014/5
Y1 - 2014/5
N2 - Using a combination of chromatographic methods, one new flavonol glycoside, myricetin 3,7-di-O-α-L-rhamnopyranoside (1), and nine known compounds myricitrin (2), quercetin 3,7-di-O-α-L-rhamnopyranoside (3), quercitrin (4), desmanthin-1 (5), myricetin 3-O-(3″-O-galloyl)-α-L- rhamnopyranoside (6), (+)-catechin (7), benzyl O-β-D-glucopyranoside (8), 2-phenylethyl O-β-D-glucopyranoside (9), and corilagin (10) were isolated from the leaves of Ardisia splendens Pit. Based on an in vitro test against Coxsackie viruses A16 by SRB assay, only compounds 2, 5, and 10 exhibited activity against Coxsackie viruses A16 with IC50 values of 40.1, 32.2, and 30.5 μM, respectively. This result suggested that compounds 2, 5, and 10 might be potential agents for treating hand, foot and mouth diseases.
AB - Using a combination of chromatographic methods, one new flavonol glycoside, myricetin 3,7-di-O-α-L-rhamnopyranoside (1), and nine known compounds myricitrin (2), quercetin 3,7-di-O-α-L-rhamnopyranoside (3), quercitrin (4), desmanthin-1 (5), myricetin 3-O-(3″-O-galloyl)-α-L- rhamnopyranoside (6), (+)-catechin (7), benzyl O-β-D-glucopyranoside (8), 2-phenylethyl O-β-D-glucopyranoside (9), and corilagin (10) were isolated from the leaves of Ardisia splendens Pit. Based on an in vitro test against Coxsackie viruses A16 by SRB assay, only compounds 2, 5, and 10 exhibited activity against Coxsackie viruses A16 with IC50 values of 40.1, 32.2, and 30.5 μM, respectively. This result suggested that compounds 2, 5, and 10 might be potential agents for treating hand, foot and mouth diseases.
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U2 - 10.1177/1934578x1400900513
DO - 10.1177/1934578x1400900513
M3 - Article
C2 - 25026709
AN - SCOPUS:84901607584
SN - 1934-578X
VL - 9
SP - 643
EP - 645
JO - Natural product communications
JF - Natural product communications
IS - 5
ER -