Chemical components from the twigs of Caesalpinia latisiliqua and their antiviral activity

Mira Oh; Seon Ju Park; Jae Hyoung Song; Hyun Jeong Ko; Seung Hyun Kim

doi:10.1007/s11418-019-01335-2

Chemical components from the twigs of Caesalpinia latisiliqua and their antiviral activity

Mira Oh, Seon Ju Park, Jae Hyoung Song, Hyun Jeong Ko, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Three new compounds, (3S)-dihydrobonducellin 8-O-β-d-glucopyranoside (1), 3′,5′-dimethoxy-jezonolid (2), and latisilinoid (3), along with 16 known compounds, were isolated from the twigs of Caesalpinia latisiliqua (Leguminosae). The known compounds were identified as flavonoids, stilbenes, and phenolics as determined by extensive spectroscopic methods, including 1D and 2D NMR. All the isolated compounds were evaluated for their antiviral activity in HRV1B-, CVB3-, and EV71-infected cells. Among the tested compounds, three flavonoids (4–6) and two stilbenes (12 and 14) exhibited significant antiviral activity. This is the first phytochemical investigation of C. latisiliqua twigs.

Original language	English
Pages (from-to)	26-33
Number of pages	8
Journal	Journal of Natural Medicines
Volume	74
Issue number	1
DOIs	https://doi.org/10.1007/s11418-019-01335-2
Publication status	Published - 2020 Jan 1

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea (NRF) grant [NRF-2016R1A2B4006742] and the Basic Research Infrastructure Support Program [University-Centered Labs-2018R1A6A1A03023718] funded by the Ministry of Education, Science and Technology, Republic of Korea.

Publisher Copyright:
© 2019, The Japanese Society of Pharmacognosy.

All Science Journal Classification (ASJC) codes

Molecular Medicine

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title = "Chemical components from the twigs of Caesalpinia latisiliqua and their antiviral activity",

abstract = "Three new compounds, (3S)-dihydrobonducellin 8-O-β-d-glucopyranoside (1), 3′,5′-dimethoxy-jezonolid (2), and latisilinoid (3), along with 16 known compounds, were isolated from the twigs of Caesalpinia latisiliqua (Leguminosae). The known compounds were identified as flavonoids, stilbenes, and phenolics as determined by extensive spectroscopic methods, including 1D and 2D NMR. All the isolated compounds were evaluated for their antiviral activity in HRV1B-, CVB3-, and EV71-infected cells. Among the tested compounds, three flavonoids (4–6) and two stilbenes (12 and 14) exhibited significant antiviral activity. This is the first phytochemical investigation of C. latisiliqua twigs.",

author = "Mira Oh and Park, {Seon Ju} and Song, {Jae Hyoung} and Ko, {Hyun Jeong} and Kim, {Seung Hyun}",

note = "Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant [NRF-2016R1A2B4006742] and the Basic Research Infrastructure Support Program [University-Centered Labs-2018R1A6A1A03023718] funded by the Ministry of Education, Science and Technology, Republic of Korea. Publisher Copyright: {\textcopyright} 2019, The Japanese Society of Pharmacognosy.",

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doi = "10.1007/s11418-019-01335-2",

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AU - Kim, Seung Hyun

N1 - Funding Information: This research was supported by the National Research Foundation of Korea (NRF) grant [NRF-2016R1A2B4006742] and the Basic Research Infrastructure Support Program [University-Centered Labs-2018R1A6A1A03023718] funded by the Ministry of Education, Science and Technology, Republic of Korea. Publisher Copyright: © 2019, The Japanese Society of Pharmacognosy.

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Y1 - 2020/1/1

N2 - Three new compounds, (3S)-dihydrobonducellin 8-O-β-d-glucopyranoside (1), 3′,5′-dimethoxy-jezonolid (2), and latisilinoid (3), along with 16 known compounds, were isolated from the twigs of Caesalpinia latisiliqua (Leguminosae). The known compounds were identified as flavonoids, stilbenes, and phenolics as determined by extensive spectroscopic methods, including 1D and 2D NMR. All the isolated compounds were evaluated for their antiviral activity in HRV1B-, CVB3-, and EV71-infected cells. Among the tested compounds, three flavonoids (4–6) and two stilbenes (12 and 14) exhibited significant antiviral activity. This is the first phytochemical investigation of C. latisiliqua twigs.

AB - Three new compounds, (3S)-dihydrobonducellin 8-O-β-d-glucopyranoside (1), 3′,5′-dimethoxy-jezonolid (2), and latisilinoid (3), along with 16 known compounds, were isolated from the twigs of Caesalpinia latisiliqua (Leguminosae). The known compounds were identified as flavonoids, stilbenes, and phenolics as determined by extensive spectroscopic methods, including 1D and 2D NMR. All the isolated compounds were evaluated for their antiviral activity in HRV1B-, CVB3-, and EV71-infected cells. Among the tested compounds, three flavonoids (4–6) and two stilbenes (12 and 14) exhibited significant antiviral activity. This is the first phytochemical investigation of C. latisiliqua twigs.

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Chemical components from the twigs of Caesalpinia latisiliqua and their antiviral activity

Abstract

Bibliographical note

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