TY - JOUR
T1 - Chemical components from the leaves of Ardisia insularis and their cytotoxic activity
AU - Van, Nguyen Thi Hong
AU - Vien, Trinh Anh
AU - Van Kiem, Phan
AU - Van Minh, Chau
AU - Nhiem, Nguyen Xuan
AU - Long, Pham Quoc
AU - Anh, Luu Tuan
AU - Kim, Nanyoung
AU - Park, Seonju
AU - Kim, Seung Hyun
N1 - Publisher Copyright:
© 2015 The Pharmaceutical Society of Korea.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - One new oleanane triterpene glycoside, ardinsuloside (1), and twelve known compounds, demethoxybergenin (2), norbergenin (3), bergenin (4), 4-O-galloylbergenin (5), quercitrin (6), myricitrin (7), myricetin 3-O-(3′′-O-galloyl)-α-l-rhamnopyranoside (8), desmanthine-2 (9), epicatechin 3-O-galloyl ester (10), 3′-methoxyepicatechin 3-O-galloyl ester (11), gallic acid (12), and methyl galloate (13) were isolated from the leaves of Ardisia insularis. Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on three cancer cell lines namely A-549 (human lung cancer), HT-29 (Human colon adenocarcinoma), and OVCAR (human ovarian carcinoma). The results revealed that compound 1 inhibited A-549, HT-29, and OVCAR cell lines with IC50 values of 8.5 ± 1.2, 16.4 ± 3.1, and 13.6 ± 2.4 μM, respectively. The remaining compound showed weak cytotoxic activity. This result indicated that compound 1 could be useful in the treatment of cancer disease.
AB - One new oleanane triterpene glycoside, ardinsuloside (1), and twelve known compounds, demethoxybergenin (2), norbergenin (3), bergenin (4), 4-O-galloylbergenin (5), quercitrin (6), myricitrin (7), myricetin 3-O-(3′′-O-galloyl)-α-l-rhamnopyranoside (8), desmanthine-2 (9), epicatechin 3-O-galloyl ester (10), 3′-methoxyepicatechin 3-O-galloyl ester (11), gallic acid (12), and methyl galloate (13) were isolated from the leaves of Ardisia insularis. Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on three cancer cell lines namely A-549 (human lung cancer), HT-29 (Human colon adenocarcinoma), and OVCAR (human ovarian carcinoma). The results revealed that compound 1 inhibited A-549, HT-29, and OVCAR cell lines with IC50 values of 8.5 ± 1.2, 16.4 ± 3.1, and 13.6 ± 2.4 μM, respectively. The remaining compound showed weak cytotoxic activity. This result indicated that compound 1 could be useful in the treatment of cancer disease.
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U2 - 10.1007/s12272-015-0591-x
DO - 10.1007/s12272-015-0591-x
M3 - Article
C2 - 25794927
AN - SCOPUS:84947129806
SN - 0253-6269
VL - 38
SP - 1926
EP - 1931
JO - Archives of pharmacal research
JF - Archives of pharmacal research
IS - 11
ER -
