Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells

Nguyen Xuan Nhiem; Nguyen Trung Tuong; Pham Thanh Ky; Lalita Subedi; Seon Ju Park; Tran Minh Ngoc; Pham Hai Yen; Bui Huu Tai; Tran Hong Quang; Phan Van Kiem; Sun Yeou Kim; Seung Hyun Kim

doi:10.1002/cbdv.201700013

Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells

Nguyen Xuan Nhiem, Nguyen Trung Tuong, Pham Thanh Ky, Lalita Subedi, Seon Ju Park, Tran Minh Ngoc, Pham Hai Yen, Bui Huu Tai, Tran Hong Quang, Phan Van Kiem, Sun Yeou Kim, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Phaeanthus vietnamensis Bân is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8′R)-9,9′-epoxy-3,5,3′,5′-tetramethoxylignan-4,4′,7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-4-acetyl-2-[(E)-(cinnamoyloxy)]-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC₅₀ values of 15.7 ± 1.2 μm. Compounds 2, 7, and 8 significantly inhibited inflammatory NO production with IC₅₀ values ranging from 22.6 to 25.3 μm.

Original language	English
Article number	e1700013
Journal	Chemistry and Biodiversity
Volume	14
Issue number	8
DOIs	https://doi.org/10.1002/cbdv.201700013
Publication status	Published - 2017 Aug

Bibliographical note

Funding Information:
This research is funded by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2015.79 and was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (NRF-2016R1A2B4006742).

Publisher Copyright:
© 2017 Wiley-VHCA AG, Zurich, Switzerland

All Science Journal Classification (ASJC) codes

Bioengineering
Biochemistry
Chemistry(all)
Molecular Medicine
Molecular Biology

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10.1002/cbdv.201700013

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@article{d0e23f01c5754c5c8235add0f3bad2dc,

title = "Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells",

abstract = "Phaeanthus vietnamensis B{\^a}n is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8′R)-9,9′-epoxy-3,5,3′,5′-tetramethoxylignan-4,4′,7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-4-acetyl-2-[(E)-(cinnamoyloxy)]-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50 values of 15.7 ± 1.2 μm. Compounds 2, 7, and 8 significantly inhibited inflammatory NO production with IC50 values ranging from 22.6 to 25.3 μm.",

author = "Nhiem, {Nguyen Xuan} and Tuong, {Nguyen Trung} and Ky, {Pham Thanh} and Lalita Subedi and Park, {Seon Ju} and Ngoc, {Tran Minh} and Yen, {Pham Hai} and Tai, {Bui Huu} and Quang, {Tran Hong} and Kiem, {Phan Van} and Kim, {Sun Yeou} and Kim, {Seung Hyun}",

note = "Funding Information: This research is funded by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2015.79 and was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (NRF-2016R1A2B4006742). Publisher Copyright: {\textcopyright} 2017 Wiley-VHCA AG, Zurich, Switzerland",

year = "2017",

month = aug,

doi = "10.1002/cbdv.201700013",

language = "English",

volume = "14",

journal = "Chemistry and Biodiversity",

issn = "1612-1872",

publisher = "Wiley-VCH Verlag",

number = "8",

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T1 - Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells

AU - Nhiem, Nguyen Xuan

AU - Tuong, Nguyen Trung

AU - Ky, Pham Thanh

AU - Subedi, Lalita

AU - Park, Seon Ju

AU - Ngoc, Tran Minh

AU - Yen, Pham Hai

AU - Tai, Bui Huu

AU - Quang, Tran Hong

AU - Kiem, Phan Van

AU - Kim, Sun Yeou

AU - Kim, Seung Hyun

N1 - Funding Information: This research is funded by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2015.79 and was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (NRF-2016R1A2B4006742). Publisher Copyright: © 2017 Wiley-VHCA AG, Zurich, Switzerland

PY - 2017/8

Y1 - 2017/8

N2 - Phaeanthus vietnamensis Bân is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8′R)-9,9′-epoxy-3,5,3′,5′-tetramethoxylignan-4,4′,7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-4-acetyl-2-[(E)-(cinnamoyloxy)]-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50 values of 15.7 ± 1.2 μm. Compounds 2, 7, and 8 significantly inhibited inflammatory NO production with IC50 values ranging from 22.6 to 25.3 μm.

AB - Phaeanthus vietnamensis Bân is a well-known medicinal plant which has been used for the treatment of various inflammatory diseases in traditional medicine. Using various chromatographic methods, three new compounds, (7S,8R,8′R)-9,9′-epoxy-3,5,3′,5′-tetramethoxylignan-4,4′,7-triol (1), 8α-hydroxyoplop-11(12)-en-14-one (5), and (1R,2S,4S)-4-acetyl-2-[(E)-(cinnamoyloxy)]-1-methylcyclohexan-1-ol (12) along with twelve known compounds were isolated from the leaves of P. vietnamensis. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated BV2 cells. As the results, compound 6 showed the most potent inhibitory activity on LPS-stimulated NO production in BV2 cells with the IC50 values of 15.7 ± 1.2 μm. Compounds 2, 7, and 8 significantly inhibited inflammatory NO production with IC50 values ranging from 22.6 to 25.3 μm.

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IS - 8

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ER -

Chemical Components from Phaeanthus vietnamensis and Their Inhibitory NO Production in BV2 Cells

Abstract

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