Chemical and Physical Characteristics of Doxorubicin Hydrochloride Drug-Doped Salmon DNA Thin Films

Bramaramba Gnapareddy, Sreekantha Reddy Dugasani, Taewoo Ha, Bjorn Paulson, Taehyun Hwang, Taesung Kim, Jae Hoon Kim, Kyunghwan Oh, Sung Ha Park

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44 Citations (Scopus)


Double-stranded salmon DNA (SDNA) was doped with doxorubicin hydrochloride drug molecules (DOX) to determine the binding between DOX and SDNA, and DOX optimum doping concentration in SDNA. SDNA thin films were prepared with various concentrations of DOX by drop-casting on oxygen plasma treated glass and quartz substrates. Fourier transform infrared (FTIR) spectroscopy was employed to investigate the binding sites for DOX in SDNA, and electrical and photoluminescence (PL) analyses were used to determine the optimum doping concentration of DOX. The FTIR spectra showed that up to a concentration of μM of DOX, there was a tendency for binding with a periodic orientation via intercalation between nucleosides. The current and PL intensity increased as the DOX concentration increased up to μM, and then as the concentration of DOX further increased, we observed a decrease in current as well as PL quenching. Finally, the optical band gap and second band onset of the transmittance spectra were analyzed to further verify the DOX binding and optimum doping concentration into SDNA thin films as a function of the DOX concentration.

Original languageEnglish
Article number12722
JournalScientific reports
Publication statusPublished - 2015 Jul 31

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (MSIP) and the Ministry of Education, Science and Technology (MEST) of the Korean government with grants to SRD (NRF-2013R1A1A2061731) and KO, SHP, and JHK (NRF-2012M3A7B4049800, NRF-2012M3A7B4049801, and NRF-2012M3A7B4049802).

All Science Journal Classification (ASJC) codes

  • General


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