A new Rh(I)-catalyzed β-alkylation of 4-phenyl-3-buten-2-one (1) was developed by utilizing diethylamine (5a) as a chelation-assistant tool. The key feature of this reaction is the vinyl C-H activation driven by amine-assisted cyclometalation to give the β,γ-unsaturated ketones 7 as a major product.
Bibliographical noteFunding Information:
This work was supported by the National Research Laboratory Program (2000-N-NL-01-C-271) administered by Ministry of Science and Technology. Authors acknowledge the Brain Korea 21 project.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry