Chelation-assisted β-alkylation of α,β-unsaturated ketone using Rh(I) catalyst and dialkyl amine

Chul Ho Jun; Choong Woon Moon; Young Min Kim; Hyuk Lee; Jun Hee Lee

doi:10.1016/S0040-4039(02)00769-4

Chelation-assisted β-alkylation of α,β-unsaturated ketone using Rh(I) catalyst and dialkyl amine

Chul Ho Jun, Choong Woon Moon, Young Min Kim, Hyuk Lee, Jun Hee Lee

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

A new Rh(I)-catalyzed β-alkylation of 4-phenyl-3-buten-2-one (1) was developed by utilizing diethylamine (5a) as a chelation-assistant tool. The key feature of this reaction is the vinyl C-H activation driven by amine-assisted cyclometalation to give the β,γ-unsaturated ketones 7 as a major product.

Original language	English
Pages (from-to)	4233-4236
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	23
DOIs	https://doi.org/10.1016/S0040-4039(02)00769-4
Publication status	Published - 2002 Jun 3

Bibliographical note

Funding Information:
This work was supported by the National Research Laboratory Program (2000-N-NL-01-C-271) administered by Ministry of Science and Technology. Authors acknowledge the Brain Korea 21 project.

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(02)00769-4

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abstract = "A new Rh(I)-catalyzed β-alkylation of 4-phenyl-3-buten-2-one (1) was developed by utilizing diethylamine (5a) as a chelation-assistant tool. The key feature of this reaction is the vinyl C-H activation driven by amine-assisted cyclometalation to give the β,γ-unsaturated ketones 7 as a major product.",

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note = "Funding Information: This work was supported by the National Research Laboratory Program (2000-N-NL-01-C-271) administered by Ministry of Science and Technology. Authors acknowledge the Brain Korea 21 project.",

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doi = "10.1016/S0040-4039(02)00769-4",

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T1 - Chelation-assisted β-alkylation of α,β-unsaturated ketone using Rh(I) catalyst and dialkyl amine

AU - Jun, Chul Ho

AU - Moon, Choong Woon

AU - Kim, Young Min

AU - Lee, Hyuk

AU - Lee, Jun Hee

N1 - Funding Information: This work was supported by the National Research Laboratory Program (2000-N-NL-01-C-271) administered by Ministry of Science and Technology. Authors acknowledge the Brain Korea 21 project.

PY - 2002/6/3

Y1 - 2002/6/3

N2 - A new Rh(I)-catalyzed β-alkylation of 4-phenyl-3-buten-2-one (1) was developed by utilizing diethylamine (5a) as a chelation-assistant tool. The key feature of this reaction is the vinyl C-H activation driven by amine-assisted cyclometalation to give the β,γ-unsaturated ketones 7 as a major product.

AB - A new Rh(I)-catalyzed β-alkylation of 4-phenyl-3-buten-2-one (1) was developed by utilizing diethylamine (5a) as a chelation-assistant tool. The key feature of this reaction is the vinyl C-H activation driven by amine-assisted cyclometalation to give the β,γ-unsaturated ketones 7 as a major product.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Chelation-assisted β-alkylation of α,β-unsaturated ketone using Rh(I) catalyst and dialkyl amine

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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