TY - JOUR
T1 - Characteristics of type 2 diabetes in terms of insulin resistance in Korea
AU - Park, Jong Suk
AU - Kim, Chul Sik
AU - Nam, Joo Young
AU - Kim, Dol Mi
AU - Jo, Min Ho
AU - Park, Jina
AU - Ahn, Chul Woo
AU - Cha, Bong Soo
AU - Lim, Sung Kil
AU - Kim, Kyung Rae
AU - Lee, Hyun Chul
AU - Huh, Kap Bum
PY - 2005/8/31
Y1 - 2005/8/31
N2 - The aim of this study was to assess the implications of insulin resistance on the clinical and biochemical profiles of Korean type 2 diabetic patients. 122 patients with type 2 diabetes underwent a short insulin tolerance test to assess insulin resistance. Subjects were classified in tertiles according to ISI (insulin sensitivity index), and the tertile I (the insulin-resistant group) and tertile III (the insulin-sensitive group) clinical and biochemical parameters were compared. Age, waist circumference (WC), systolic blood pressure (SBP), HbA1c, body fat content, and fasting plasma glucose were significantly higher in tertile I than tertile III (all p<0.05). The frequency of hypertension and family history of cerebrovascular disease (CVD) were greater in tertile I than III (p< 0.05). To evaluate the factors affecting ISI, multiple regression was performed, and age, WC, SBP, HbA1c, and body fat content were found to be independently related to insulin resistance (p<0.05). Old age, hypertension, central obesity, and poor glycemic control were identified as clinical parameters of insulin resistance in Korean type 2 diabetic patients.
AB - The aim of this study was to assess the implications of insulin resistance on the clinical and biochemical profiles of Korean type 2 diabetic patients. 122 patients with type 2 diabetes underwent a short insulin tolerance test to assess insulin resistance. Subjects were classified in tertiles according to ISI (insulin sensitivity index), and the tertile I (the insulin-resistant group) and tertile III (the insulin-sensitive group) clinical and biochemical parameters were compared. Age, waist circumference (WC), systolic blood pressure (SBP), HbA1c, body fat content, and fasting plasma glucose were significantly higher in tertile I than tertile III (all p<0.05). The frequency of hypertension and family history of cerebrovascular disease (CVD) were greater in tertile I than III (p< 0.05). To evaluate the factors affecting ISI, multiple regression was performed, and age, WC, SBP, HbA1c, and body fat content were found to be independently related to insulin resistance (p<0.05). Old age, hypertension, central obesity, and poor glycemic control were identified as clinical parameters of insulin resistance in Korean type 2 diabetic patients.
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U2 - 10.3349/ymj.2005.46.4.484
DO - 10.3349/ymj.2005.46.4.484
M3 - Article
C2 - 16127772
AN - SCOPUS:24644515317
SN - 0513-5796
VL - 46
SP - 484
EP - 490
JO - Yonsei Medical Journal
JF - Yonsei Medical Journal
IS - 4
ER -
