Characteristics of patients presented with metastases during or after completion of chemoradiation therapy for locally advanced rectal cancer: A case series

Radwan Torky, Mohammed Alessa, Ho Seung Kim, Ahmed Sakr, Eman Zakarneh, Fozan Sauri, Heejin Bae, Nam Kyu Kim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Purpose: Locally advanced rectal cancer (LARC) is managed by chemoradiotherapy (CRT), followed by surgery. Herein we reported patients with metastases during or after CRT. Methods: Data of patients with LARC who received CRT from 2008 to 2017 were reviewed. Patients with metastases after CRT were included. Those with metastatic tumors at the initial diagnosis were excluded. Results: Fourteen patients (1.3%) of 1,092 who received CRT presented with metastases. Magnetic resonance circumferential resection margin (mrCRM) and mesorectal lymph nodes (LNs) were positive in 12 patients (85.7%). Meanwhile, magnetic resonance extramural vascular invasion (mrEMVI) was positive in 10 patients (71.4%). Magnetic resonance tumor regression grade (mrTRG) 4 and mrTRG5 was detected in 5 and 1 patient respectively. Ten patients (71.4%) underwent combined surgery and 3 (21.4%) received palliative chemotherapy. Conclusion: Patients with metastases after CRT showed a higher rate of positive mrCRM, mrEMVI, mesorectal LNs, and poor tumor response. Further studies with a large number of patients are necessary for better survival outcomes in LARC.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalAnnals of Coloproctology
Volume37
Issue number3
DOIs
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 The Korean Society of Coloproctology.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology

Fingerprint

Dive into the research topics of 'Characteristics of patients presented with metastases during or after completion of chemoradiation therapy for locally advanced rectal cancer: A case series'. Together they form a unique fingerprint.

Cite this