Characteristics of korean patients with primary adrenal insufficiency: A registry-based nationwide survey in Korea

The Korean Adrenal Gland and Endocrine Hypertension Study Group, Korean Endocrine Society

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background: Primary adrenal insufficiency (PAI) is a rare, potentially life-threatening condition. There are few Korean studies on PAI, and most have had small sample sizes. We aimed to examine the etiology, clinical characteristics, treatment, and mortality of PAI in Korean patients. Methods: A nationwide, multicenter, registry-based survey was conducted to identify adults diagnosed with or treated for PAI at 30 secondary or tertiary care institutions in Korea between 2000 and 2014. Results: A total of 269 patients with PAI were identified. The prevalence of PAI was 4.17 per million. The estimated incidence was 0.45 per million per year. The mean age at diagnosis was 49.0 years, and PAI was more prevalent in men. Adrenal tuberculosis was the most common cause of PAI in patients diagnosed before 2000; for those diagnosed thereafter, adrenal metastasis and tuberculosis were comparable leading causes. The etiology of PAI was not identified in 34.9% of cases. Of the patients receiving glucocorticoid replacement therapy, prednisolone was more frequently administered than hydrocortisone (69.4% vs. 26.5%, respectively), and only 27.1% of all patients received fludrocortisone. We observed an increased prevalence of metabolic disease and osteoporosis during the follow-up period (median, 60.2 months). The observed overall mortality and disease-specific mortality rates were 11.9% and 3.1%, respectively. Conclusion: The prevalence of PAI is significantly lower in Koreans than in reports from Western countries. The high frequency undetermined etiology in patients with PAI suggests the need to reveal accurate etiology of PAI in Korea.

Original languageEnglish
Pages (from-to)466-474
Number of pages9
JournalEndocrinology and Metabolism
Issue number4
Publication statusPublished - 2017 Dec 1

Bibliographical note

Funding Information:
This study was supported by the Korean Endocrine Society of EnM Research Award 2016, and the Korean Adrenal Gland and Endocrine Hypertension Study Group.

Publisher Copyright:
© 2017 Korean Endocrine Society.

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Characteristics of korean patients with primary adrenal insufficiency: A registry-based nationwide survey in Korea'. Together they form a unique fingerprint.

Cite this